ELOVL3 - ELOVL fatty acid elongase 3 Gene

Homo sapiens

Also known as CIG30; CIG-30

Gene ID: 83401 | Gene type: protein coding

About ELOVL3

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:102,224,767-102,229,589 (from NCBI)

This gene has 1 transcript (splice variant), 264 orthologues and 6 paralogues. Biased expression in fat (RPKM 1.4), skin (RPKM 0.7) and 8 other tissues.

Summary

This gene encodes a protein that belongs to the GNS1/SUR4 family. Members of this family play a role in elongation of long chain fatty acids to provide precursors for synthesis of sphingolipids and ceramides. [provided by RefSeq, Jul 2013]

ELOVL3 Products(1)

mRNA	Protein	Name
NM_152310.3	NP_689523.1	elongation of very long chain fatty acids protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fatty acid elongase activity	EXP EXP: Inferred from Experiment	10970790	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20937905	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in fatty acid elongation, monounsaturated fatty acid	IDA IDA: Inferred from direct assay	20937905	GOA
involved in fatty acid elongation, polyunsaturated fatty acid	IDA IDA: Inferred from direct assay	20937905	GOA
involved in fatty acid elongation, saturated fatty acid	IDA IDA: Inferred from direct assay	20937905	GOA
involved in very long-chain fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	20937905	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	20937905	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELOVL3 Protein Structure

ELO

0
100
200
270 a.a.

Protein Preferred Names

Protein Names

elongation of very long chain fatty acids protein 3

3-keto acyl-CoA synthase ELOVL3

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 38

Spinocerebellar Ataxia Type 38	SCA38
Ataxia, Spinocerebellar, Type 38

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-152947	ELOVL6-IN-4		98.63%	Unkown
HY-RS04323	ELOVL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ELOVL3	VGNC	VGNC:72064
Mus musculus	ELOVL3	MGD	MGI:1195976
Canis familiaris	ELOVL3	VGNC	VGNC:40321
Rattus norvegicus	ELOVL3	RGD	RGD:1307263
Bos taurus	ELOVL3	VGNC	VGNC:28449

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