2. Gene
  3. ADPGK - ADP dependent glucokinase Gene

ADPGK - ADP dependent glucokinase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ADP-GK; 2610017G09Rik

Gene ID: 83440 | Gene type: protein coding

About ADPGK

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:72,751,294-72,783,758 (from NCBI)

This gene has 14 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in bone marrow (RPKM 23.6), appendix (RPKM 19.7) and 25 other tissues.

Summary

ADPGK (EC 2.7.1.147) catalyzes the ADP-dependent phosphorylation of glucose to glucose-6-phosphate and may play a role in glycolysis, possibly during ischemic conditions (Ronimus and Morgan, 2004 [PubMed 14975750]).[supplied by OMIM, Mar 2008]

ADPGK Products(8)

mRNA Protein Name
NM_001365223.1 NP_001352152.1 ADP-dependent glucokinase isoform 2
NM_001365224.1 NP_001352153.1 ADP-dependent glucokinase isoform 3
NM_001365225.1 NP_001352154.1 ADP-dependent glucokinase isoform 4 precursor
NM_001365226.1 NP_001352155.1 ADP-dependent glucokinase isoform 5
NM_001365227.1 NP_001352156.1 ADP-dependent glucokinase isoform 6 precursor
NM_001365228.1 NP_001352157.1 ADP-dependent glucokinase isoform 7 precursor
NM_001365229.1 NP_001352158.1 ADP-dependent glucokinase isoform 3
NM_031284.5 NP_112574.3 ADP-dependent glucokinase isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ADP-specific glucokinase activity EXP
EXP: Inferred from Experiment
23168256 GOA
enables ADP-specific glucokinase activity IDA
IDA: Inferred from direct assay
26555263 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within glucose metabolic process IDA
IDA: Inferred from direct assay
26555263 GOA
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
23168256 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADPGK Protein Structure

ADP_PFK_GK

ADP_PFK_GK: ADP-specific Phosphofructokinase/Glucokinase conserved region (69 - 491)

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  • 496 a.a.
Protein Preferred Names Protein Names

ADP-dependent glucokinase

ATP-dependent glucokinase

Related Diseases

Diseases Alias
Mycobacterium Tuberculosis 1

Tuberculosis

Tuberculoma

Tuberculosis, Susceptibility To

Mycobacterium Tuberculosis, Susceptibility To, 1

Mtbs1

TB
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00403 ADPGK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ADPGK RGD RGD:1306103
Mus musculus ADPGK MGD MGI:1919391
Macaca mulatta ADPGK VGNC VGNC:69692
Bos taurus ADPGK VGNC VGNC:25689
Canis familiaris ADPGK VGNC VGNC:37669
Felis catus ADPGK VGNC VGNC:59651