SCRT1 - scratch family transcriptional repressor 1 Gene

Homo sapiens

Also known as SCRT; ZNF898

Gene ID: 83482 | Gene type: protein coding

About SCRT1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,330,565-144,336,482 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 238 orthologues and 36 paralogues. Biased expression in brain (RPKM 4.1), adrenal (RPKM 0.6) and 1 other tissue.

Summary

This gene encodes a C2H2-type zinc finger transcriptional repressor that binds to E-box motifs. The encoded protein may promote neural differention and may be involved in cancers with neuroendocrine features. [provided by RefSeq, Jul 2013]

SCRT1 Products(1)

mRNA	Protein	Name
NM_031309.6	NP_112599.2	transcriptional repressor scratch 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11274425	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11274425	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23332764	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11274425	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCRT1 Protein Structure

zf-C2H2

zf-C2H2_4

zf-H2C2_2

0
100
200
300
348 a.a.

Protein Preferred Names

Protein Names

transcriptional repressor scratch 1

scratch family zinc finger 1

Related Diseases

Diseases

Alias

Fumarase Deficiency

Fumaric Aciduria	FMRD
Fumarate Hydratase Deficiency	Deficiency, Fumarase

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12565	SCRT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SCRT1	VGNC	VGNC:34369
Mus musculus	SCRT1	MGD	MGI:2176606
Rattus norvegicus	SCRT1	RGD	RGD:1306236
Macaca mulatta	SCRT1	VGNC	VGNC:77021

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