2. Gene
  3. Aplnr - apelin receptor Gene

Aplnr - apelin receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Apj; Agtrl1

Gene ID: 83518 | Gene type: protein coding

About Aplnr

Primary_assembly 3: 70,217,385-70,221,050 forward strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 172 orthologues, 8 paralogues and is associated with 2 phenotypes.

Summary

Predicted to enable apelin receptor activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of cAMP-mediated signaling; and regulation of body fluid levels. Located in plasma membrane. Orthologous to human APLNR (apelin receptor). [provided by Alliance of Genome Resources, Apr 2022]

Aplnr Products(1)

mRNA Protein Name
NM_031349.2 NP_112639.1 apelin receptor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11359874 RGD
involved in negative regulation of cAMP-mediated signaling IMP
IMP: Inferred from mutant phenotype
11359874 RGD
involved in regulation of body fluid levels IMP
IMP: Inferred from mutant phenotype
12787050 RGD
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
11359874 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Aplnr Protein Structure

7tmA_Apelin_R

7tmA_Apelin_R: cd15190 (16 - 317)

7tmA_Apelin_R

7tmA_Apelin_R: cd15190 (27 - 53)

7tmA_Apelin_R

7tmA_Apelin_R: cd15190 (61 - 86)

7tmA_Apelin_R

7tmA_Apelin_R: cd15190 (99 - 129)

7tmA_Apelin_R

7tmA_Apelin_R: cd15190 (142 - 163)

7tmA_Apelin_R

7tmA_Apelin_R: cd15190 (195 - 224)

7tmA_Apelin_R

7tmA_Apelin_R: cd15190 (238 - 268)

7tmA_Apelin_R

7tmA_Apelin_R: cd15190 (285 - 310)

  • 0
  • 100
  • 200
  • 300
  • 377 a.a.
Protein Preferred Names Protein Names

apelin receptor

B78

G-protein coupled receptor APJ

GPCR34

angiotensin receptor-like 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P2271 MM 54 Inhibitor 99.16% Unkown
HY-126293 Apelin agonist 1 Agonist / Unkown
HY-147751 APJ receptor agonist 6 / Unkown
HY-RS00823 APLNR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00824 Aplnr Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00825 Aplnr Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aplnr NCBI NCBI:187