H3C8 - H3 clustered histone 8 Gene

Homo sapiens

Also known as H3/h; H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3FH; H3C10; H3C11; H3C12; HIST1H3G

Gene ID: 8355 | Gene type: protein coding

About H3C8

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,270,918-26,271,413 (from NCBI)

This gene has 1 transcript (splice variant), 70 orthologues and 20 paralogues.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

H3C8 Products(1)

mRNA	Protein	Name
NM_003534.3	NP_003525.1	histone H3.1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IDA IDA: Inferred from direct assay	30867594	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10949293	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in epigenetic regulation of gene expression	IDA IDA: Inferred from direct assay	16267050	GOA
acts upstream of positive effect gene expression	IDA IDA: Inferred from direct assay	30867594	GOA
involved in nucleosome assembly	IDA IDA: Inferred from direct assay	14718166	GOA
involved in nucleosome assembly	IMP IMP: Inferred from mutant phenotype	25615412	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of nucleosome	IDA IDA: Inferred from direct assay	14718166	GOA
part of nucleosome	IPI IPI: Inferred from physical interaction	21812398	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21636898	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	14718166	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H3C8 Protein Structure

Histone

0
100
136 a.a.

Protein Preferred Names

Protein Names

histone H3.1

H3 histone family, member H

Recombinant H3C8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72332	Histone H3 Protein, Human	P68431 (A2-A136)	≥95%
HY-P72335	Histone H3 Protein, Human (98a.a, His)	P68431 (P39-A136)	≥95%
HY-P72798	Histone H3 Protein, Human (His)	P68431 (A2-A136)	≥95%

Related Diseases

Diseases

Alias

Adult Infiltrating Astrocytic Neoplasm

Adult Infiltrating Astrocytoma

Adult Infiltrating Astrocytic Tumor

Histone Mutated Tumor

Histone Mutated Tumour

Diffuse Midline Glioma, H3 K27m-Mutant

Diffuse Intrinsic Pontine Glioma	Dipg
Infiltrative Brainstem Glioma

Anaplastic Oligodendroglioma, Idh-Mutant And 1p/19q-Codeleted

Brain Stem Cancer

Brain Stem Neoplasms	Malignant Neoplasm Of Brain Stem
Malignant Neoplasm Of Brainstem	Neoplasm Of Adult Brain Stem
Neoplasm Of Brain Stem	Primary Brain Stem Neoplasm
Primary Brain Stem Tumor	Brain Stem Neoplasm
Brain Stem--Cancer	Brain Stem Neoplasms, Primary

Hutchinson-Gilford Progeria Syndrome

Progeria	HGPS
Hutchinson-Gilford Syndrome	Hutchinson-Gilford Progeria
Hutchinson Gilford Syndrome	Hutchinson Gilford Progeria Syndrome
Hutchinson-Gilford Disease	Progeria Of Childhood
Hutchinson-Gilford-Progeria Syndrome

Childhood Brain Stem Glioma

Pediatric Glioma Of The Brainstem

Diffuse Large B-Cell Lymphoma

Dlbcl	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Large B-Cell Diffuse Lymphoma	Lymphoma, Large B-Cell, Diffuse
Dlbcl - [Diffuse Large B-Cell Lymphoma]	Diffuse Large Beta Cell Lymphoma

Posterior Fossa Ependymoma

Tonsil Squamous Cell Carcinoma

Tonsillar Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Palatine Tonsil

Adult Astrocytic Tumour

Adult Astrocytoma

Adult Astrocytic Tumors

Pilomyxoid Astrocytoma

Pilocytic Astrocytoma

Juvenile Pilocytic Astrocytoma	Grade I Astrocytic Tumor
Piloid Astrocytoma

Low Grade Glioma

Benign Glioma

Central Nervous System Benign Neoplasm

Benign Neoplasm Of The Central Nervous System

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05972	H3C8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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