CASP6 - caspase 6 Gene

Rattus norvegicus

Also known as Mch2

Gene ID: 83584 | Gene type: protein coding

About CASP6

Primary_assembly 2: 218,466,076-218,478,502 forward strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 268 orthologues, 12 paralogues and is associated with 16 phenotypes. Biased expression in Thymus (RPKM 132.6), Liver (RPKM 128.) and 9 other tissues.

Summary

Enables endopeptidase activity. Involved in several processes, including acute inflammatory response to non-antigenic stimulus; axonal fasciculation; and positive regulation of programmed cell death. Located in several cellular components, including axon; cytosol; and neuronal cell body. Used to study status epilepticus. Biomarker of brain ischemia; endometritis; middle cerebral artery infarction; and prostate carcinoma. Human ortholog(s) of this gene implicated in ovarian carcinoma. Orthologous to human CASP6 (Caspase 6). [provided by Alliance of Genome Resources, Apr 2022]

CASP6 Products(2)

mRNA	Protein	Name
NM_001271984.1	NP_001258913.1	caspase-6
NM_031775.3	NP_113963.2	caspase-6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables endopeptidase activity	IDA IDA: Inferred from direct assay	12081569	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in acute inflammatory response to non-antigenic stimulus	IDA IDA: Inferred from direct assay	18175566	RGD
involved in axonal fasciculation	IMP IMP: Inferred from mutant phenotype	25898930	RGD
involved in lens development in camera-type eye	IEP IEP: Inferred from expression pattern	15161922	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12606487	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	11433428	RGD
involved in positive regulation of retinal cell programmed cell death	IMP IMP: Inferred from mutant phenotype	12917395	RGD
involved in response to cytokine	IDA IDA: Inferred from direct assay	15201138	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	12967350	RGD
involved in response to gamma radiation	IEP IEP: Inferred from expression pattern	10590178	RGD
involved in response to glucose	IMP IMP: Inferred from mutant phenotype	12606487	RGD
involved in response to hydrogen peroxide	IDA IDA: Inferred from direct assay	17571084	RGD
involved in response to iron ion	IMP IMP: Inferred from mutant phenotype	17571084	RGD
involved in response to metal ion	IEP IEP: Inferred from expression pattern	11960910	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	12724284	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	16733813	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	25898930	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	25898930	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CASP6 Protein Structure

CASc

0
100
200
277 a.a.

Protein Preferred Names

Protein Names

caspase-6

CASP-6

apoptotic protease Mch-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01959	CASP6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01960	Casp6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01961	CASP6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	CASP6	NCBI	NCBI:839

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