SELENOO - selenoprotein O Gene

Homo sapiens

Also known as SELO

Gene ID: 83642 | Gene type: protein coding

About SELENOO

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,201,011-50,217,616 (from NCBI)

This gene has 2 transcripts (splice variants) and 243 orthologues. Ubiquitous expression in bone marrow (RPKM 10.3), liver (RPKM 10.3) and 25 other tissues.

Summary

This gene encodes a selenoprotein that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The exact function of this selenoprotein is not known, but it is thought to have redox activity. [provided by RefSeq, Dec 2016]

SELENOO Products(1)

mRNA	Protein	Name
NM_031454.2	NP_113642.1	protein adenylyltransferase SelO, mitochondrial

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables AMPylase activity	IDA IDA: Inferred from direct assay	30270044	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein adenylylation	IDA IDA: Inferred from direct assay	30270044	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	24751718	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SELENOO Protein Structure

UPF0061

0
200
400
600
669 a.a.

Protein Preferred Names

Protein Names

protein adenylyltransferase SelO, mitochondrial

Related Diseases

Diseases

Alias

Staphyloenterotoxemia

Staphylococcal Food Poisoning	Staphylococcal Toxaemia Due To Food
Staphyloenterotoxicosis

Epidermolysis Bullosa Simplex 5a, Ogna Type

Epidermolysis Bullosa Simplex, Ogna Type	EBS5A
Ebsog	Epidermolysis Bullosa Simplex Ogna Type
Ebs-Og	Ebs-O
Plec-Related Intermediate Epidermolysis Bullosa Simplex Without Extracutaneous Involvement	Plec-Related Intermediate Ebs Without Extracutaneous Involvement
Ebs1	Ebso
Epidermolysis Bullosa Simplex 1	O-Ebs
Simplex Epidermolysis Bullosa_ogna Type

Commensal Bacterial Infectious Disease

Ritter'S Disease

Staphylococcal Scalded Skin Syndrome	Pemphigus Neonatorum
Ritter Disease	Dermatitis Exfoliativa Neonatorum
Scalded Skin Syndrome	Toxic Epidermal Necrolysis, Subcorneal Type
Generalized Exfoliative Disease	Ssss
Ssss - [Staphylococcal Scalded Skin Syndrome]

Rocky Mountain Spotted Fever

Brazillian Spotted	Choix
Exanthematic Typhus Of Sao Paulo	Fiebre Maculosa
Fiebre Manchada	Sao Paulo Typhus
So Paulo Fever	Tick Typhus
Tobia Fever	Rmsf
Typhus, Tick

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12640	SELENOO Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SELENOO	VGNC	VGNC:109513
Bos taurus	SELENOO	VGNC	VGNC:58445
Rattus norvegicus	SELENOO	RGD	RGD:1311907
Mus musculus	SELENOO	MGD	MGI:1919007
Canis familiaris	SELENOO	VGNC	VGNC:54544
Macaca mulatta	SELENOO	VGNC	VGNC:98474

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