DYNLRB1 - dynein light chain roadblock-type 1 Gene

Homo sapiens

Also known as BLP; BITH; DNCL2A; DNLC2A; ROBLD1

Gene ID: 83658 | Gene type: protein coding

About DYNLRB1

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:34,515,602-34,540,958 (from NCBI)

This gene has 5 transcripts (splice variants), 162 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 34.0), kidney (RPKM 31.8) and 25 other tissues.

Summary

This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013]

DYNLRB1 Products(5)

mRNA	Protein	Name
NM_001319157.2	NP_001306086.1	dynein light chain roadblock-type 1 isoform d
NM_001382365.1	NP_001369294.1	dynein light chain roadblock-type 1 isoform a
NM_001382366.1	NP_001369295.1	dynein light chain roadblock-type 1 isoform e
NM_001382367.1	NP_001369296.1	dynein light chain roadblock-type 1 isoform f
NM_014183.4	NP_054902.1	dynein light chain roadblock-type 1 isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
part of dynein complex	IPI IPI: Inferred from physical interaction	24986880	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DYNLRB1 Protein Structure

Robl_LC7

0
96 a.a.

Protein Preferred Names

Protein Names

dynein light chain roadblock-type 1

ROBL/LC7-like 1

DYNLRB1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DYNLRB1	Q9NP97	MAGEA2	Homo sapiens	P43356	Y2H Prey Pooling	32296183
Intra	DYNLRB1	Q9NP97	MAGEA2	Homo sapiens	P43356	Y2H Array	32296183
Intra	DYNLRB1	Q9NP97	DYNC1I2	Homo sapiens	Q13409	Validated Y2H	25416956
Intra	DYNLRB1	Q9NP97	DYNC1I2	Homo sapiens	Q13409	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Tuberculous Empyema

Empyema, Tuberculous

Empyema Tuberculous

Vestibular Nystagmus

Nystagmus Associated With Disorder Of The Vestibular System

Asphyxiating Thoracic Dystrophy

Jeune Thoracic Dystrophy	Jeune Syndrome
Asphyxiating Thoracic Dysplasia	Short-Rib Thoracic Dysplasia With Or Without Polydactyly
Thoracic Pelvic Phalangeal Dystrophy	Asphyxiating Thoracic Chondrodystrophy
Atd	Chondroectodermal Dysplasia-Like Syndrome
Infantile Thoracic Dystrophy	Jeune Thoracic Dysplasia
Thoracic Asphyxiant Dystrophy	Thoracic-Pelvic-Phalangeal Dystrophy
Short-Rib Thoracic Dysplasia Without Polydactyly	Asphyxiating Thoracic Dystrophy Of The Newborn
Asphyxiating Thorax Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04090	DYNLRB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DYNLRB1	VGNC	VGNC:40152
Bos taurus	DYNLRB1	VGNC	VGNC:28276
Felis catus	DYNLRB1	VGNC	VGNC:61682
Macaca mulatta	DYNLRB1	VGNC	VGNC:71839
Rattus norvegicus	DYNLRB1	RGD	RGD:619910
Mus musculus	DYNLRB1	MGD	MGI:1914318

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