1. Gene
  2. PARP9 - poly(ADP-ribose) polymerase family member 9 Gene

PARP9 - poly(ADP-ribose) polymerase family member 9 Gene

Homo sapiens

Also known as BAL; BAL1; ARTD9; MGC:7868

Gene ID: 83666 | Gene type: protein coding

About PARP9

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:122,527,924-122,564,784 (from NCBI)

This gene has 8 transcripts (splice variants), 250 orthologues and 8 paralogues. Ubiquitous expression in spleen (RPKM 10.3), appendix (RPKM 10.1) and 25 other tissues.

Summary

Enables several functions, including ADP-D-ribose binding activity; NAD+ ADP-ribosyltransferase activity; and STAT family protein binding activity. Involved in several processes, including positive regulation of nitrogen compound metabolic process; regulation of defense response; and regulation of gene expression. Located in several cellular components, including mitochondrion; nucleoplasm; and site of DNA damage. Part of protein-containing complex. Colocalizes with nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PARP9 Products(23)

mRNA Protein Name
NM_001146102.2 NP_001139574.1 protein mono-ADP-ribosyltransferase PARP9 isoform a
NM_001146103.2 NP_001139575.1 protein mono-ADP-ribosyltransferase PARP9 isoform b
NM_001146104.2 NP_001139576.1 protein mono-ADP-ribosyltransferase PARP9 isoform b
NM_001146105.2 NP_001139577.1 protein mono-ADP-ribosyltransferase PARP9 isoform b
NM_001146106.3 NP_001139578.1 protein mono-ADP-ribosyltransferase PARP9 isoform c
NM_001387871.1 NP_001374800.1 protein mono-ADP-ribosyltransferase PARP9 isoform a
NM_001387872.1 NP_001374801.1 protein mono-ADP-ribosyltransferase PARP9 isoform a
NM_001387873.1 NP_001374802.1 protein mono-ADP-ribosyltransferase PARP9 isoform d
NM_001387874.1 NP_001374803.1 protein mono-ADP-ribosyltransferase PARP9 isoform d
NM_001387875.1 NP_001374804.1 protein mono-ADP-ribosyltransferase PARP9 isoform b
NM_001387876.1 NP_001374805.1 protein mono-ADP-ribosyltransferase PARP9 isoform b
NM_001387877.1 NP_001374806.1 protein mono-ADP-ribosyltransferase PARP9 isoform b
NM_001387878.1 NP_001374807.1 protein mono-ADP-ribosyltransferase PARP9 isoform e
NM_001387879.1 NP_001374808.1 protein mono-ADP-ribosyltransferase PARP9 isoform e
NM_001387880.1 NP_001374809.1 protein mono-ADP-ribosyltransferase PARP9 isoform f
NM_001387881.1 NP_001374810.1 protein mono-ADP-ribosyltransferase PARP9 isoform g
NM_001387882.1 NP_001374811.1 protein mono-ADP-ribosyltransferase PARP9 isoform g
NM_001387883.1 NP_001374812.1 protein mono-ADP-ribosyltransferase PARP9 isoform g
NM_001387884.1 NP_001374813.1 protein mono-ADP-ribosyltransferase PARP9 isoform g
NM_001387885.1 NP_001374814.1 protein mono-ADP-ribosyltransferase PARP9 isoform c
NM_001387886.1 NP_001374815.1 protein mono-ADP-ribosyltransferase PARP9 isoform c
NM_001387887.1 NP_001374816.1 protein mono-ADP-ribosyltransferase PARP9 isoform c
NM_031458.3 NP_113646.2 protein mono-ADP-ribosyltransferase PARP9 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ADP-D-ribose binding IMP
IMP: Inferred from mutant phenotype
26479788 GOA
NOT enables NAD+ binding IMP
IMP: Inferred from mutant phenotype
16061477 GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
23230272 GOA
NOT enables NAD+-protein poly-ADP-ribosyltransferase activity IMP
IMP: Inferred from mutant phenotype
16061477 GOA
enables NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
28525742 GOA
enables STAT family protein binding IPI
IPI: Inferred from physical interaction
26479788 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
27796300 GOA
enables enzyme inhibitor activity IDA
IDA: Inferred from direct assay
27796300 GOA
enables histone binding IPI
IPI: Inferred from physical interaction
26479788 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16809771 GOA
enables transcription corepressor activity IMP
IMP: Inferred from mutant phenotype
16061477 GOA
enables ubiquitin-like protein ligase binding IPI
IPI: Inferred from physical interaction
28525742 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
28525742 GOA
involved in double-strand break repair IMP
IMP: Inferred from mutant phenotype
23230272 GOA
involved in negative regulation of catalytic activity IDA
IDA: Inferred from direct assay
27796300 GOA
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
27796300 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16061477 GOA
involved in positive regulation of DNA-templated transcription IGI
IGI: Inferred from genetic interaction
26479788 GOA
involved in positive regulation of chromatin binding IGI
IGI: Inferred from genetic interaction
26479788 GOA
involved in positive regulation of defense response to virus by host IGI
IGI: Inferred from genetic interaction
26479788 GOA
involved in positive regulation of protein localization to nucleus IGI
IGI: Inferred from genetic interaction
26479788 GOA
involved in positive regulation of type II interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
27796300 GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein IMP
IMP: Inferred from mutant phenotype
27796300 GOA
involved in post-transcriptional regulation of gene expression IMP
IMP: Inferred from mutant phenotype
26479788 GOA
NOT involved in protein poly-ADP-ribosylation IMP
IMP: Inferred from mutant phenotype
16061477 GOA
involved in regulation of response to type II interferon IDA
IDA: Inferred from direct assay
16809771 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16809771 GOA
colocalizes with nucleus IDA
IDA: Inferred from direct assay
26479788 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16809771 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
26479788 GOA
located in site of DNA damage IDA
IDA: Inferred from direct assay
28525742 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARP9 Protein Structure

Macro

Macro: Macro domain (136 - 253)

Macro

Macro: Macro domain (335 - 446)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 854 a.a.
Protein Preferred Names Protein Names

protein mono-ADP-ribosyltransferase PARP9

ADP-ribosyltransferase diphtheria toxin-like 9

Related Diseases

Diseases Alias
Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos

B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos

Osebold-Remondini Syndrome

Brachydactyly Type A6

Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities

Bda6

Brachydactyly, Type A6

Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome

ARCS1

Arthrogryposis Renal Dysfunction Cholestasis Syndrome

Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome

Arcs

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, And Cholestasis

Arthrogryposis-Renal Dysfunction-Cholestasis

Arthrogryposis - Renal Dysfunction - Cholestasis

Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1

Arthrogryposis Renal Dysfunction And Cholestasis 1

Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1

Kidney Failure

Renal Insufficiency

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PARP9 RGD RGD:1307534
Mus musculus PARP9 MGD MGI:1933117
Macaca mulatta PARP9 VGNC VGNC:84057
Bos taurus PARP9 VGNC VGNC:53596
Felis catus PARP9 VGNC VGNC:102799
Canis familiaris PARP9 VGNC VGNC:53084