HYAL3 - hyaluronidase 3 Gene

Homo sapiens

Also known as LUCA3; HYAL-3; LUCA-3

Gene ID: 8372 | Gene type: protein coding

About HYAL3

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,292,832-50,299,405 (from NCBI)

This gene has 7 transcripts (splice variants), 180 orthologues and 4 paralogues. Broad expression in bone marrow (RPKM 11.6), testis (RPKM 6.6) and 20 other tissues.

Summary

This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase Enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]

HYAL3 Products(5)

mRNA	Protein	Name
NM_001200029.2	NP_001186958.1	hyaluronidase-3 isoform 1 precursor
NM_001200030.2	NP_001186959.1	hyaluronidase-3 isoform 2 precursor
NM_001200031.2	NP_001186960.1	hyaluronidase-3 isoform 3
NM_001200032.2	NP_001186961.1	hyaluronidase-3 isoform 4
NM_003549.4	NP_003540.2	hyaluronidase-3 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables hyaluronoglucuronidase activity	IDA IDA: Inferred from direct assay	21699545	GOA
NOT enables hyalurononglucosaminidase activity	IDA IDA: Inferred from direct assay	12084718	GOA
enables hyalurononglucosaminidase activity	IDA IDA: Inferred from direct assay	11944887	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
NOT enables virus receptor activity	IDA IDA: Inferred from direct assay	11296287	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cartilage development	IEP IEP: Inferred from expression pattern	11944887	GOA
involved in cellular response to UV-B	IDA IDA: Inferred from direct assay	21699545	GOA
involved in cellular response to interleukin-1	IDA IDA: Inferred from direct assay	18390475	GOA
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	18390475	GOA
involved in hyaluronan catabolic process	IDA IDA: Inferred from direct assay	12084718	GOA
involved in inflammatory response	IDA IDA: Inferred from direct assay	18390475	GOA
involved in response to antibiotic	IEP IEP: Inferred from expression pattern	11944887	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	11296287	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	18390475	GOA
located in lysosome	IDA IDA: Inferred from direct assay	16600643	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HYAL3 Protein Structure

Glyco_hydro_56

0
100
200
300
417 a.a.

Protein Preferred Names

Protein Names

hyaluronidase-3

hyaluronoglucosaminidase 3

HYAL3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HYAL3	O43820	BOLL	Homo sapiens	Q8N9W6-4	Validated Y2H	32296183
Intra	HYAL3	O43820	BOLL	Homo sapiens	Q8N9W6-4	Y2H Array	32296183
Intra	HYAL3	O43820	BOLL	Homo sapiens	Q8N9W6-4	Y2H Prey Pooling	32296183
Intra	HYAL3	O43820	CAMK2A	Homo sapiens	Q9UQM7	Y2H Prey Pooling	32296183
Intra	HYAL3	O43820	CAMK2A	Homo sapiens	Q9UQM7	Validated Y2H	32296183
Intra	HYAL3	O43820	CAMK2A	Homo sapiens	Q9UQM7	Y2H Array	32296183
Intra	HYAL3	O43820	DAB1	Homo sapiens	O75553	Validated Y2H	25416956
Intra	HYAL3	O43820	DAB1	Homo sapiens	O75553	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Aqueous Misdirection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06497	HYAL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HYAL3	VGNC	VGNC:67680
Rattus norvegicus	HYAL3	RGD	RGD:1303334
Mus musculus	HYAL3	MGD	MGI:1330288
Macaca mulatta	HYAL3	VGNC	VGNC:84169
Bos taurus	HYAL3	VGNC	VGNC:106776
Canis familiaris	HYAL3	VGNC	VGNC:81270

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