GRWD1 - glutamate rich WD repeat containing 1 Gene

Homo sapiens

Also known as CDW4; GRWD; RRB1; WDR28

Gene ID: 83743 | Gene type: protein coding

About GRWD1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,445,983-48,457,022 (from NCBI)

This gene has 3 transcripts (splice variants), 180 orthologues and 9 paralogues. Ubiquitous expression in placenta (RPKM 6.8), appendix (RPKM 6.7) and 25 other tissues.

Summary

This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 Ligase. [provided by RefSeq, Feb 2012]

GRWD1 Products(1)

mRNA	Protein	Name
NM_031485.4	NP_113673.3	glutamate-rich WD repeat-containing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA replication origin binding	IDA IDA: Inferred from direct assay	25990725	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	25990725	GOA
enables histone binding	IDA IDA: Inferred from direct assay	25990725	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17041588	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA replication	IMP IMP: Inferred from mutant phenotype	25990725	GOA
involved in nucleosome assembly	IDA IDA: Inferred from direct assay	25990725	GOA
involved in nucleosome assembly	IMP IMP: Inferred from mutant phenotype	27552915	GOA
involved in nucleosome disassembly	IMP IMP: Inferred from mutant phenotype	27552915	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	25990725	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23349634	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRWD1 Protein Structure

CAF1C_H4-bd

WD40

0
100
200
300
400
446 a.a.

Protein Preferred Names

Protein Names

glutamate-rich WD repeat-containing protein 1

CUL4- and DDB1-associated WDR protein 4

Related Diseases

Diseases

Alias

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05850	GRWD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GRWD1	VGNC	VGNC:73213
Bos taurus	GRWD1	VGNC	VGNC:29669
Canis familiaris	GRWD1	VGNC	VGNC:41521
Rattus norvegicus	GRWD1	RGD	RGD:1310649
Felis catus	GRWD1	VGNC	VGNC:62722
Mus musculus	GRWD1	MGD	MGI:2141989

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