TAS1R3 - taste 1 receptor member 3 Gene

Homo sapiens

Also known as T1R3

Gene ID: 83756 | Gene type: protein coding

About TAS1R3

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,331,280-1,335,314 (from NCBI)

This gene has 1 transcript (splice variant), 202 orthologues and 4 paralogues. Broad expression in salivary gland (RPKM 1.8), duodenum (RPKM 0.7) and 22 other tissues.

Summary

The protein encoded by this gene is a G-protein coupled receptor involved in taste responses. The encoded protein can form a heterodimeric receptor with TAS1R1 to elicit the umami taste response, or it can bind with TAS1R2 to form a receptor for the sweet taste response. [provided by RefSeq, Nov 2015]

TAS1R3 Products(1)

mRNA	Protein	Name
NM_152228.3	NP_689414.2	taste receptor type 1 member 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to sweet taste receptor activity	IDA IDA: Inferred from direct assay	16720576	GOA
contributes to taste receptor activity	IDA IDA: Inferred from direct assay	16720576	GOA
enables taste receptor activity	IPI IPI: Inferred from physical interaction	11917125	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in detection of chemical stimulus involved in sensory perception of sweet taste	IDA IDA: Inferred from direct assay	16720576	GOA
involved in sensory perception of sweet taste	IDA IDA: Inferred from direct assay	11917125	GOA
involved in sensory perception of umami taste	IDA IDA: Inferred from direct assay	11917125	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of sweet taste receptor complex	IDA IDA: Inferred from direct assay	16720576	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAS1R3 Protein Structure

ANF_receptor

NCD3G

7tm_3

0
200
400
600
800
852 a.a.

Protein Preferred Names

Protein Names

taste receptor type 1 member 3

sweet taste receptor T1R3

Related Diseases

Diseases

Alias

Dental Caries

Dental Caries Extending Into Pulp	Dental Caries Of Smooth Surface
Dental Caries Pit And Fissure	Smooth Surface Dental Caries
Dental Decay	Carious Teeth
Dental Cavity	Saprodontia
Teeth Decayed	Tooth Caries
Tooth Decay

Renal Pelvis Transitional Cell Carcinoma

Urothelial Cell Carcinoma Of Renal Pelvis	Renal Pelvis Urothelial Carcinoma
Transitional Cell Carcinoma Of Renal Pelvis

Glucocorticoid Deficiency 1

Acth Resistance	Glucocorticoid Deficiency, Due To Acth Unresponsiveness
GCCD1	Familial Glucocorticoid Deficiency 1
Fgd1	Adrenal Unresponsiveness To Acth
Hereditary Unresponsiveness To Adrenocorticotropic Hormone	Isolated Glucocorticoid Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14214	TAS1R3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TAS1R3	VGNC	VGNC:47113
Macaca mulatta	TAS1R3	VGNC	VGNC:106513
Bos taurus	TAS1R3	VGNC	VGNC:106965
Rattus norvegicus	TAS1R3	RGD	RGD:620539
Felis catus	TAS1R3	VGNC	VGNC:80375
Mus musculus	TAS1R3	MGD	MGI:1933547

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