USP26 - ubiquitin specific peptidase 26 Gene

Homo sapiens

Gene ID: 83844 | Gene type: protein coding

About USP26

Cytogenetic location: Xq26.2 Genomic coordinates (GRCh38): X:133,023,168-133,097,109 (from NCBI)

This gene has 3 transcripts (splice variants), 15 orthologues and 71 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases and is a deubiquitinating Enzyme (DUB) with His and Cys domains. It is specifically expressed in testis tissue. Mutations in this gene have been associated with Sertoli cell-only syndrome and male infertility. [provided by RefSeq, Jul 2008]

USP26 Products(1)

mRNA	Protein	Name
NM_031907.3	NP_114113.1	ubiquitin carboxyl-terminal hydrolase 26

USP26 Protein Structure

UCH

0
200
400
600
800
913 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 26

deubiquitinating enzyme 26

Related Diseases

Diseases

Alias

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Infertility

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Spermatogenic Failure, X-Linked, 1

Sertoli Cell-Only Syndrome	Germinal Cell Aplasia
Del Castillo Syndrome	SPGFX1
X-Linked Spermatogenic Failure 1	Congenital Absence Of Germinal Epithelium Of Testes

Tonne-Kalscheuer Syndrome

TOKAS	Mrx61
Intellectual Developmental Disorder With Or Without Hand And Foot Anomalies, Genital Anomalies, Or Congenital Diaphragmatic Hernia	Mental Retardation, X-Linked 61
X-Linked Mental Retardation 61

Benign Pleural Mesothelioma

Mesothelioma Of Pleura	Benign Neoplasm Of Mesothelial Tissue Of Pleura
Pleural Malignant Mesothelioma

Acquired Hyperkeratosis

Acquired Keratoderma	Keratoderma - Acquired
Keratoderma, Acquired	Keratosis Blennorrhagica

Vas Deferens, Congenital Bilateral Aplasia Of

Congenital Bilateral Absence Of Vas Deferens	CBAVD
Cavd	Congenital Bilateral Aplasia Of Vas Deferens
Congenital Bilateral Absence Of The Vas Deferens	Congenital Bilateral Agenesis Of Vas Deferens
Absence Of Vas Deferens	Absent Vasa
Congenital Absence Of Vas Deferens	Congenital Aplasia Of Vas Deferens
Absent Vas Deferens	Vas Deferens, Congenital Bilateral Absence

Oligospermia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15536	USP26 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	USP26	RGD	RGD:1563443
Bos taurus	USP26	VGNC	VGNC:36719
Canis familiaris	USP26	VGNC	VGNC:48185
Mus musculus	USP26	MGD	MGI:1933247

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