RAB34 - RAB34, member RAS oncogene family Gene

Homo sapiens

Also known as RAH; NARR; RAB39

Gene ID: 83871 | Gene type: protein coding

About RAB34

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,714,281-28,718,428 (from NCBI)

This gene has 26 transcripts (splice variants), 191 orthologues and 68 paralogues. Ubiquitous expression in ovary (RPKM 30.9), endometrium (RPKM 28.1) and 23 other tissues.

Summary

This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript variants. An alternatively spliced transcript variant produces the nine-amino acid residue-repeats (NARR) protein, which is a functionally distinct nucleolar protein resulting from a different reading frame. [provided by RefSeq, Dec 2016]

RAB34 Products(9)

mRNA	Protein	Name
NM_001142624.2	NP_001136096.2	ras-related protein Rab-34 isoform 2
NM_001142625.2	NP_001136097.2	ras-related protein Rab-34 isoform 3
NM_001144942.2	NP_001138414.1	ras-related protein Rab-34 isoform 4
NM_001144943.1	NP_001138415.1	ras-related protein Rab-34 isoform 5
NM_001256276.2	NP_001243205.1	ras-related protein Rab-34 isoform 6
NM_001256277.2	NP_001243206.1	ras-related protein Rab-34 isoform 1
NM_001256278.1	NP_001243207.1	ras-related protein Rab-34 isoform 7
NM_001256281.3	NP_001243210.1	ras-related protein Rab-34 isoform NARR
NM_031934.6	NP_114140.4	ras-related protein Rab-34 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP-dependent protein binding	IPI IPI: Inferred from physical interaction	16138900	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16138900	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	24056301	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi to plasma membrane protein transport	IDA IDA: Inferred from direct assay	17881736	GOA
involved in antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	19717423	GOA
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	37384395	GOA
involved in lysosome localization	IDA IDA: Inferred from direct assay	17881736	GOA
NOT involved in macropinocytosis	IDA IDA: Inferred from direct assay	17881736	GOA
involved in phagosome maturation	IMP IMP: Inferred from mutant phenotype	21255211	GOA
involved in phagosome-lysosome fusion	IMP IMP: Inferred from mutant phenotype	21255211	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	17881736	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	16138900	GOA
located in Golgi cisterna	IDA IDA: Inferred from direct assay	17881736	GOA
located in Golgi stack	IDA IDA: Inferred from direct assay	17881736	GOA
located in centriole	IDA IDA: Inferred from direct assay	37384395	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16138900	GOA
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	21255211	GOA
NOT located in ruffle membrane	IDA IDA: Inferred from direct assay	17881736	GOA
located in vesicle	IDA IDA: Inferred from direct assay	17881736	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB34 Protein Structure

Ras

0
100
200
259 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-34

nine amino-acid residue-repeats

Related Diseases

Diseases

Alias

N Syndrome

NSX	Intellectual Disability, Malformations, Chromosome Breakage, And Development Of T-Cell Leukemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11548	RAB34 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RAB34	VGNC	VGNC:45277
Rattus norvegicus	RAB34	RGD	RGD:1305058
Macaca mulatta	RAB34	VGNC	VGNC:81533
Bos taurus	RAB34	VGNC	VGNC:106887
Mus musculus	RAB34	MGD	MGI:104606

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