GPR61 - G protein-coupled receptor 61 Gene

Homo sapiens

Also known as BALGR; GPCR3

Gene ID: 83873 | Gene type: protein coding

About GPR61

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,539,872-109,547,260 (from NCBI)

This gene has 7 transcripts (splice variants), 247 orthologues and 3 paralogues. Biased expression in brain (RPKM 1.2), thyroid (RPKM 0.5) and 3 other tissues.

Summary

This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is most closely related to biogenic amine receptors. [provided by RefSeq, Jul 2008]

GPR61 Products(2)

mRNA	Protein	Name
NM_001393907.1	NP_001380836.1	G-protein coupled receptor 61
NM_031936.6	NP_114142.3	G-protein coupled receptor 61

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables arrestin family protein binding	IDA IDA: Inferred from direct assay	28827538	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28827538	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28827538	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endosome	IDA IDA: Inferred from direct assay	28827538	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	28827538	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR61 Protein Structure

7tm_1

0
100
200
300
400
451 a.a.

Protein Preferred Names

Protein Names

G-protein coupled receptor 61

biogenic amine receptor-like G-protein coupled receptor

GPR61 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GPR61	Q9BZJ8	SLC13A4	Homo sapiens	Q9UKG4	Y2H Array	32296183
Intra	GPR61	Q9BZJ8	SLC13A4	Homo sapiens	Q9UKG4	Y2H Prey Pooling	32296183
Intra	GPR61	Q9BZJ8	SLC13A4	Homo sapiens	Q9UKG4	Validated Y2H	32296183
Intra	GPR61	Q9BZJ8	SLC12A7	Homo sapiens	Q9Y666-2	Y2H Array	32296183
Intra	GPR61	Q9BZJ8	SLC12A7	Homo sapiens	Q9Y666-2	Y2H Prey Pooling	32296183
Intra	GPR61	Q9BZJ8	SLC12A7	Homo sapiens	Q9Y666-2	Validated Y2H	32296183
Intra	GPR61	Q9BZJ8	GJB6	Homo sapiens	O95452	Y2H Array	32296183
Intra	GPR61	Q9BZJ8	GJB6	Homo sapiens	O95452	Y2H Prey Pooling	32296183
Intra	GPR61	Q9BZJ8	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	GPR61	Q9BZJ8	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	GPR61	Q9BZJ8	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	GPR61	Q9BZJ8	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	GPR61	Q9BZJ8	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	GPR61	Q9BZJ8	ARL6IP6	Homo sapiens	Q8N6S5	Y2H Array	32296183
Intra	GPR61	Q9BZJ8	ARL6IP6	Homo sapiens	Q8N6S5	Y2H Prey Pooling	32296183
Intra	GPR61	Q9BZJ8	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	GPR61	Q9BZJ8	CLDND1	Homo sapiens	Q9NY35	Validated Y2H	32296183
Intra	GPR61	Q9BZJ8	KLRC1	Homo sapiens	P26715	Y2H Prey Pooling	32296183
Intra	GPR61	Q9BZJ8	KLRC1	Homo sapiens	P26715	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Olfactory Groove Meningioma

Meningioma Of The Olfactory Groove

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156354	GPR61 Inverse agonist 1		99.33%	Unkown
HY-RS05727	GPR61 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GPR61	VGNC	VGNC:54028
Macaca mulatta	GPR61	VGNC	VGNC:72933
Felis catus	GPR61	VGNC	VGNC:62692
Bos taurus	GPR61	VGNC	VGNC:29593
Rattus norvegicus	GPR61	RGD	RGD:1310176
Mus musculus	GPR61	MGD	MGI:2441719

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