MIXL1 - Mix paired-like homeobox Gene

Homo sapiens

Also known as MIX; MIXL; MILD1

Gene ID: 83881 | Gene type: protein coding

About MIXL1

Cytogenetic location: 1q42.12 Genomic coordinates (GRCh38): 1:226,223,664-226,227,060 (from NCBI)

This gene has 3 transcripts (splice variants), 153 orthologues and 50 paralogues. Biased expression in lymph node (RPKM 1.1), urinary bladder (RPKM 0.8) and 11 other tissues.

Summary

Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005 [PubMed 15982639]).[supplied by OMIM, Mar 2008]

MIXL1 Products(2)

mRNA	Protein	Name
NM_001282402.2	NP_001269331.1	homeobox protein MIXL1 isoform 1
NM_031944.3	NP_114150.1	homeobox protein MIXL1 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	22164283	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MIXL1 Protein Structure

Homeobox

0
100
200
232 a.a.

Protein Preferred Names

Protein Names

homeobox protein MIXL1

MIX1 homeobox-like protein 1

Related Diseases

Diseases

Alias

Fanconi Anemia, Complementation Group F

Fanconi Anemia Complementation Group F

FANCF

Germ Cell And Embryonal Cancer

Germ Cell And Embryonal Neoplasm

Germ Cell Cancer

Malignant Germ Cell Tumor	Neoplasms, Germ Cell And Embryonal
Germ Cell Neoplasm	Germ Cell Tumour
Malignant Tumor Of The Germ Cell	Neoplasms Germ Cell
Malignant Germ Cell Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08469	MIXL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MIXL1	VGNC	VGNC:74730
Bos taurus	MIXL1	VGNC	VGNC:31488
Rattus norvegicus	MIXL1	RGD	RGD:1310011
Mus musculus	MIXL1	MGD	MGI:1351322

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