EIF2A - eukaryotic translation initiation factor 2A Gene

Homo sapiens

Also known as CDA02; EIF-2A; MST089; MSTP004; MSTP089

Gene ID: 83939 | Gene type: protein coding

About EIF2A

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:150,546,787-150,586,016 (from NCBI)

This gene has 16 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in thyroid (RPKM 30.8), ovary (RPKM 23.5) and 25 other tissues.

Summary

This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

EIF2A Products(5)

mRNA	Protein	Name
NM_001319043.2	NP_001305972.1	eukaryotic translation initiation factor 2A isoform 2
NM_001319044.2	NP_001305973.1	eukaryotic translation initiation factor 2A isoform 3
NM_001319045.2	NP_001305974.1	eukaryotic translation initiation factor 2A isoform 4
NM_001319046.2	NP_001305975.1	eukaryotic translation initiation factor 2A isoform 5
NM_032025.5	NP_114414.2	eukaryotic translation initiation factor 2A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ribosome binding	IMP IMP: Inferred from mutant phenotype	12133843	GOA
enables tRNA binding	IMP IMP: Inferred from mutant phenotype	12133843	GOA
enables translation initiation factor activity	IDA IDA: Inferred from direct assay	10563826	GOA
enables translation initiation factor activity	IMP IMP: Inferred from mutant phenotype	12133843	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of translation	IMP IMP: Inferred from mutant phenotype	12133843	GOA
involved in ribosome assembly	IMP IMP: Inferred from mutant phenotype	12133843	GOA
involved in translational initiation	IDA IDA: Inferred from direct assay	12133843	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12133843	GOA
part of eukaryotic translation initiation factor 2 complex	IDA IDA: Inferred from direct assay	12133843	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF2A Protein Structure

eIF2A

0
100
200
300
400
500
585 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 2A

65 kDa eukaryotic translation initiation factor 2A

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119240	CCT020312	Activator	99.05%	Unkown
HY-101991	ML291		99.74%	Unkown
HY-145835A	(S)-PERK-IN-5	Inhibitor	/	Unkown
HY-RS04241	EIF2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EIF2A	RGD	RGD:1589591
Bos taurus	EIF2A	VGNC	VGNC:28379
Felis catus	EIF2A	VGNC	VGNC:61769
Mus musculus	EIF2A	MGD	MGI:1098684
Canis familiaris	EIF2A	VGNC	VGNC:40255
Macaca mulatta	EIF2A	VGNC	VGNC:72180
Others	EIF2A	NCBI

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