2. Cell Cycle/DNA Damage Apoptosis
  3. PERK Eukaryotic Initiation Factor (eIF) Apoptosis
  4. ML291

ML291 is a UPR (unfolded protein response)-inducing sulfonamidebenzamide. ML291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and reduce leukemic cell burden.

For research use only. We do not sell to patients.

ML291 Chemical Structure

ML291 Chemical Structure

CAS No. : 1523437-16-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 99 In-stock
Solution
10 mM * 1 mL in DMSO USD 99 In-stock
Solid
5 mg USD 90 In-stock
10 mg USD 150 In-stock
25 mg USD 300 In-stock
50 mg USD 500 In-stock
100 mg USD 850 In-stock
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Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

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Description

ML291 is a UPR (unfolded protein response)-inducing sulfonamidebenzamide. ML291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and reduce leukemic cell burden[1].

IC50 & Target

eIF2

 

Cellular Effect
Cell Line Type Value Description References
IMR-90 EC50
> 25 μM
Compound: 8
Cytotoxicity against human IMR90 cells after 44 to 46 hrs by CellTiter-Blue assay
Cytotoxicity against human IMR90 cells after 44 to 46 hrs by CellTiter-Blue assay
[PMID: 28119024]
MEF EC50
> 20 μM
Compound: 12
Antiproliferative activity against CHOP-knock out MEF cells after 16 hrs by luminescence assay
Antiproliferative activity against CHOP-knock out MEF cells after 16 hrs by luminescence assay
[PMID: 25530830]
MEF EC50
4.8 μM
Compound: 12
Antiproliferative activity against wild-type MEF cells after 16 hrs by luminescence assay
Antiproliferative activity against wild-type MEF cells after 16 hrs by luminescence assay
[PMID: 25530830]
Molecular Weight

413.83

Formula

C16H16ClN3O6S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(S(=O)(N3CCC(Cl)CC3)=O)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (120.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4165 mL 12.0823 mL 24.1645 mL
5 mM 0.4833 mL 2.4165 mL 4.8329 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.74%

SDS (251 KB)

COA (247 KB) HNMR (166 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4165 mL 12.0823 mL 24.1645 mL 60.4113 mL
5 mM 0.4833 mL 2.4165 mL 4.8329 mL 12.0823 mL
10 mM 0.2416 mL 1.2082 mL 2.4165 mL 6.0411 mL
15 mM 0.1611 mL 0.8055 mL 1.6110 mL 4.0274 mL
20 mM 0.1208 mL 0.6041 mL 1.2082 mL 3.0206 mL
25 mM 0.0967 mL 0.4833 mL 0.9666 mL 2.4165 mL
30 mM 0.0805 mL 0.4027 mL 0.8055 mL 2.0137 mL
40 mM 0.0604 mL 0.3021 mL 0.6041 mL 1.5103 mL
50 mM 0.0483 mL 0.2416 mL 0.4833 mL 1.2082 mL
60 mM 0.0403 mL 0.2014 mL 0.4027 mL 1.0069 mL
80 mM 0.0302 mL 0.1510 mL 0.3021 mL 0.7551 mL
100 mM 0.0242 mL 0.1208 mL 0.2416 mL 0.6041 mL
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ML291 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ML2911523437-16-2ML 291ML-291PERKEukaryotic Initiation Factor (eIF)ApoptosisProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseleukemiaCHOP-null K562 cellsK562 cellsunfolded protein response (UPR)apoptosisInhibitorinhibitorinhibit

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