PIP4K2B - phosphatidylinositol-5-phosphate 4-kinase type 2 beta Gene

Homo sapiens

Also known as PI5P4KB; PIP5K2B; PIP5KIIB; PIP5P4KB; PIP5KIIbeta

Gene ID: 8396 | Gene type: protein coding

About PIP4K2B

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:38,765,691-38,799,556 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 191 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 40.4), ovary (RPKM 23.8) and 24 other tissues.

Summary

The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF Receptor. [provided by RefSeq, Jul 2008]

PIP4K2B Products(1)

mRNA	Protein	Name
NM_003559.5	NP_003550.1	phosphatidylinositol 5-phosphate 4-kinase type-2 beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IDA IDA: Inferred from direct assay	9038203	GOA
enables ATP binding	IDA IDA: Inferred from direct assay	26774281	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	26774281	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	9753329	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process	IDA IDA: Inferred from direct assay	26774281	GOA
involved in negative regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	31091439	GOA
involved in positive regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	25578879	GOA
involved in regulation of autophagy	IMP IMP: Inferred from mutant phenotype	25578879	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in autophagosome	IMP IMP: Inferred from mutant phenotype	25578879	GOA
located in nucleus	IDA IDA: Inferred from direct assay	30718367	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	30718367	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIP4K2B Protein Structure

PIP5K

0
100
200
300
416 a.a.

Protein Preferred Names

Protein Names

phosphatidylinositol 5-phosphate 4-kinase type-2 beta

1-phosphatidylinositol 5-phosphate 4-kinase 2-beta

Recombinant PIP4K2B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700597	PIP4K2B Protein, Human (His)	P78356 (S2-T416)	≥95%

Related Diseases

Diseases

Alias

Developmental And Epileptic Encephalopathy 33

DEE33	Epileptic Encephalopathy, Early Infantile, 33
Eiee33	Developmental And Epileptic Encephalopathy, 33
Early Infantile Epileptic Encephalopathy 33	Encephalopathy, Epileptic, Early Infantile, Type 33

Cone-Rod Dystrophy 5

CORD5

Dystrophy, Cone-Rod, Type 5

Lateral Meningocele Syndrome

Lehman Syndrome	Lms
LMNS	Meningocele, Lateral Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10563	PIP4K2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PIP4K2B	VGNC	VGNC:32907
Macaca mulatta	PIP4K2B	VGNC	VGNC:76004
Rattus norvegicus	PIP4K2B	RGD	RGD:621710
Felis catus	PIP4K2B	VGNC	VGNC:68865
Mus musculus	PIP4K2B	MGD	MGI:1934234
Canis familiaris	PIP4K2B	VGNC	VGNC:44571
Others	PIP4K2B	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.