2. Gene
  3. TMPRSS13 - transmembrane serine protease 13 Gene

TMPRSS13 - transmembrane serine protease 13 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as MSP; MSPL; MSPS; TMPRSS11

Gene ID: 84000 | Gene type: protein coding

About TMPRSS13

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:117,900,641-117,929,402 (from NCBI)

This gene has 7 transcripts (splice variants), 216 orthologues and 17 paralogues. Biased expression in skin (RPKM 9.7), esophagus (RPKM 3.1) and 4 other tissues.

Summary

This gene encodes a member of the type II transmembrane serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Transmembrane serine proteases are regulated by Protease Inhibitors and known to function in development, homeostasis, Infection, and tumorigenesis. This protein facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. [provided by RefSeq, Aug 2021]

TMPRSS13 Products(4)

mRNA Protein Name
NM_001077263.3 NP_001070731.1 transmembrane protease serine 13 isoform 1
NM_001206789.2 NP_001193718.1 transmembrane protease serine 13 isoform 2
NM_001206790.2 NP_001193719.1 transmembrane protease serine 13 isoform 3
NM_001244995.2 NP_001231924.1 transmembrane protease serine 13 isoform 4

TMPRSS13 Protein Structure

SRCR_2

SRCR_2: Scavenger receptor cysteine-rich domain (231 - 320)

Trypsin

Trypsin: Trypsin (326 - 554)

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  • 567 a.a.
Protein Preferred Names Protein Names

transmembrane protease serine 13

membrane-type mosaic serine protease

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-169250 TMPRSS13-IN-1 Inhibitor / Unkown
HY-RS14767 TMPRSS13 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TMPRSS13 VGNC VGNC:66384
Bos taurus TMPRSS13 VGNC VGNC:106988
Canis familiaris TMPRSS13 VGNC VGNC:47631
Macaca mulatta TMPRSS13 VGNC VGNC:79822
Rattus norvegicus TMPRSS13 RGD RGD:1310872
Mus musculus TMPRSS13 MGD MGI:2682935