EMILIN2 - elastin microfibril interfacer 2 Gene

Homo sapiens

Also known as FOAP-10; EMILIN-2

Gene ID: 84034 | Gene type: protein coding

About EMILIN2

Cytogenetic location: 18p11.32-p11.31 Genomic coordinates (GRCh38): 18:2,846,232-2,916,003 (from NCBI)

This gene has 3 transcripts (splice variants), 258 orthologues and 4 paralogues. Broad expression in placenta (RPKM 19.1), appendix (RPKM 17.1) and 22 other tissues.

Summary

Predicted to enable extracellular matrix constituent conferring elasticity. Predicted to be involved in cell adhesion. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

EMILIN2 Products(1)

mRNA	Protein	Name
NM_032048.3	NP_114437.2	EMILIN-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11278945	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	24374807	GOA
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	20360940	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	24374807	GOA
involved in positive regulation of defense response to bacterium	IDA IDA: Inferred from direct assay	17988845	GOA
involved in positive regulation of platelet aggregation	IDA IDA: Inferred from direct assay	25658937	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	11278945	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EMILIN2 Protein Structure

EMI

C1q

0
200
400
600
800
1000
1053 a.a.

Protein Preferred Names

Protein Names

EMILIN-2

elastin microfibril interface-located protein 2

Related Diseases

Diseases

Alias

Porokeratosis

Disseminated Superficial Actinic Porokeratosis	Dsap
Porokeratosis Of Mibelli	Porokeratosis, Disseminated Superficial Actinic
Porokeratosis, Disseminated Superficial Actinic, 1

Oropouche Fever

Oropouche Virus Disease

Oropouche Mosquito-Borne Viral Fever

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04351	EMILIN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EMILIN2	RGD	RGD:1305343
Felis catus	EMILIN2	VGNC	VGNC:61846
Canis familiaris	EMILIN2	VGNC	VGNC:40344
Macaca mulatta	EMILIN2	VGNC	VGNC:72076
Mus musculus	EMILIN2	MGD	MGI:2389136
Bos taurus	EMILIN2	VGNC	VGNC:28474

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