SRPX - sushi repeat containing protein X-linked Gene

Homo sapiens

Also known as DRS; ETX1; SRPX1; HEL-S-83p

Gene ID: 8406 | Gene type: protein coding

About SRPX

Cytogenetic location: Xp11.4 Genomic coordinates (GRCh38): X:38,149,339-38,220,871 (from NCBI)

This gene has 6 transcripts (splice variants), 190 orthologues and 39 paralogues. Broad expression in placenta (RPKM 49.3), fat (RPKM 34.8) and 19 other tissues.

Summary

Predicted to be an extracellular matrix structural constituent. Predicted to be involved in cell adhesion. Predicted to act upstream of or within several processes, including negative regulation of cell proliferation involved in contact inhibition; phagolysosome assembly; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Part of collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]

SRPX Products(4)

mRNA	Protein	Name
NM_001170750.2	NP_001164221.1	sushi repeat-containing protein SRPX isoform 2 precursor
NM_001170751.2	NP_001164222.1	sushi repeat-containing protein SRPX isoform 3 precursor
NM_001170752.2	NP_001164223.1	sushi repeat-containing protein SRPX isoform 4 precursor
NM_006307.5	NP_006298.1	sushi repeat-containing protein SRPX isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20406461	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRPX Protein Structure

Sushi

HYR

Sushi

DUF4174

0
100
200
300
400
464 a.a.

Protein Preferred Names

Protein Names

sushi repeat-containing protein SRPX

epididymis secretory sperm binding protein Li 83p

Related Diseases

Diseases

Alias

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13782	SRPX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13783	SRPX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SRPX	RGD	RGD:70950
Mus musculus	SRPX	MGD	MGI:1858306
Bos taurus	SRPX	VGNC	VGNC:50570
Others	SRPX	NCBI

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