ZNF644 - zinc finger protein 644 Gene

Homo sapiens

Also known as NatF; MYP21; ZEP-2; BM-005

Gene ID: 84146 | Gene type: protein coding

About ZNF644

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:90,915,304-91,022,035 (from NCBI)

This gene has 11 transcripts (splice variants), 242 orthologues, 51 paralogues and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 9.2), endometrium (RPKM 7.6) and 25 other tissues.

Summary

The protein encoded by this gene is a zinc finger transcription factor that may play a role in eye development. Defects in this gene have been associated with high myopia. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

ZNF644 Products(3)

mRNA	Protein	Name
NM_016620.4	NP_057704.2	zinc finger protein 644 isoform 2
NM_032186.5	NP_115562.3	zinc finger protein 644 isoform 2
NM_201269.3	NP_958357.1	zinc finger protein 644 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	25789554	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	25789554	GOA
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	29628311	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF644 Protein Structure

zf-C2H2_4

0
300
600
900
1200
1327 a.a.

Protein Preferred Names

Protein Names

zinc finger protein 644

zinc finger motif enhancer binding protein 2

Related Diseases

Diseases

Alias

Myopia 21, Autosomal Dominant

MYP21

Myopia, Type 21, Autosomal Dominant

Refractive Error

Refractive Errors

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Degenerative Myopia

Pathological Myopia	Myopia, Degenerative
Degenerative Progressive High Myopia	Progressive High Myopia
Progressive High Myopia

Anisometropia

Protoplasmic Astrocytoma

Protoplasmic Astrocytic Tumor

Astrocytoma Protoplasmic

Stickler Syndrome

Arthroophthalmopathy	Hereditary Arthro-Ophthalmo-Dystrophy
Hereditary Arthro-Ophthalmopathy	Stickler Dysplasia
Hereditary Progressive Arthroophthalmopathy	Stickler Syndrome, Type 1

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16162	ZNF644 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZNF644	MGD	MGI:1277212
Bos taurus	ZNF644	VGNC	VGNC:37320
Rattus norvegicus	ZNF644	RGD	RGD:1306805
Macaca mulatta	ZNF644	VGNC	VGNC:79789
Felis catus	ZNF644	VGNC	VGNC:67343
Canis familiaris	ZNF644	VGNC	VGNC:48784

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