MEX3B - mex-3 RNA binding family member B Gene

Homo sapiens

Also known as RKHD3; MEX-3B; RNF195

Gene ID: 84206 | Gene type: protein coding

About MEX3B

Cytogenetic location: 15q25.2 Genomic coordinates (GRCh38): 15:82,041,778-82,046,018 (from NCBI)

This gene has 2 transcripts (splice variants), 189 orthologues and 3 paralogues. Biased expression in testis (RPKM 20.7), endometrium (RPKM 5.5) and 7 other tissues.

Summary

This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is exported from the cytoplasm to the nucleus. The protein binds to RNA via two KH domains and also colocalizes with MEX3A, Dcp1A decapping factor and Argonaute proteins within P (processing) bodies. [provided by RefSeq, Oct 2012]

MEX3B Products(1)

mRNA	Protein	Name
NM_032246.6	NP_115622.2	RNA-binding protein MEX3B

MEX3B Protein Structure

KH_1

zf-C3HC4_3

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569 a.a.

Protein Preferred Names

Protein Names

RNA-binding protein MEX3B

RING finger protein 195

MEX3B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MEX3B	Q6ZN04	YWHAE	Homo sapiens	P62258	Crosslink	36931259

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08373	MEX3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MEX3B	MGD	MGI:1918252
Bos taurus	MEX3B	VGNC	VGNC:54452
Felis catus	MEX3B	VGNC	VGNC:80912
Rattus norvegicus	MEX3B	RGD	RGD:1306790
Canis familiaris	MEX3B	VGNC	VGNC:43184
Macaca mulatta	MEX3B	VGNC	VGNC:74574

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