TMEM117 - transmembrane protein 117 Gene

Homo sapiens

Gene ID: 84216 | Gene type: protein coding

About TMEM117

This gene has 8 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in esophagus (RPKM 3.1), duodenum (RPKM 2.6) and 25 other tissues.

Summary

Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Located in endoplasmic reticulum and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM117 Products(4)

mRNA	Protein	Name
NM_001286211.2	NP_001273140.1	transmembrane protein 117 isoform b
NM_001286212.2	NP_001273141.1	transmembrane protein 117 isoform c
NM_001286213.2	NP_001273142.1	transmembrane protein 117 isoform d
NM_032256.3	NP_115632.1	transmembrane protein 117 isoform a

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	28285135	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	27391701	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM117 Protein Structure

TMEM117

0
100
200
300
400
514 a.a.

Protein Preferred Names

Protein Names

transmembrane protein 117

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14654	TMEM117 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TMEM117	RGD	RGD:1562562
Macaca mulatta	TMEM117	VGNC	VGNC:79488
Bos taurus	TMEM117	VGNC	VGNC:35954
Mus musculus	TMEM117	MGD	MGI:2444580
Canis familiaris	TMEM117	VGNC	VGNC:47454

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