PSMG3 - proteasome assembly chaperone 3 Gene

Homo sapiens

Also known as PAC3; C7orf48

Gene ID: 84262 | Gene type: protein coding

About PSMG3

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:1,567,332-1,570,032 (from NCBI)

This gene has 3 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in bone marrow (RPKM 8.7), skin (RPKM 6.6) and 25 other tissues.

Summary

Enables molecular adaptor activity. Involved in chaperone-mediated protein complex assembly. Predicted to be part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

PSMG3 Products(2)

mRNA	Protein	Name
NM_001134340.2	NP_001127812.1	proteasome assembly chaperone 3
NM_032302.4	NP_115678.1	proteasome assembly chaperone 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular adaptor activity	IMP IMP: Inferred from mutant phenotype	17189198	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17189198	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	17189198	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chaperone-mediated protein complex assembly	IMP IMP: Inferred from mutant phenotype	17189198	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMG3 Protein Structure

PAC3

0
100
122 a.a.

Protein Preferred Names

Protein Names

proteasome assembly chaperone 3

PAC-3

Related Diseases

Diseases

Alias

Robinow Syndrome, Autosomal Dominant 1

Autosomal Dominant Robinow Syndrome 1	DRS1
Robinow Dwarfism	Fetal Face Syndrome
Acral Dysostosis With Facial And Genital Abnormalities	Robinow, Autosomal Dominant Syndrome, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11338	PSMG3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PSMG3	VGNC	VGNC:64416
Macaca mulatta	PSMG3	VGNC	VGNC:76301
Bos taurus	PSMG3	VGNC	VGNC:33480
Mus musculus	PSMG3	MGD	MGI:1913756
Rattus norvegicus	PSMG3	RGD	RGD:2319950
Canis familiaris	PSMG3	VGNC	VGNC:45123
Others	PSMG3	NCBI

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