2. Gene
  3. ALKBH7 - alkB homolog 7 Gene

ALKBH7 - alkB homolog 7 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as ABH7; SPATA11; UNQ6002

Gene ID: 84266 | Gene type: protein coding

About ALKBH7

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,372,794-6,375,250 (from NCBI)

This gene has 3 transcripts (splice variants) and 192 orthologues. Broad expression in testis (RPKM 38.0), kidney (RPKM 14.9) and 24 other tissues.

Summary

Predicted to enable dioxygenase activity and metal ion binding activity. Involved in cellular response to DNA damage stimulus and regulation of mitochondrial membrane permeability involved in programmed necrotic cell death. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]

ALKBH7 Products(1)

mRNA Protein Name
NM_032306.4 NP_115682.1 alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
23666923 GOA
involved in regulation of mitochondrial membrane permeability involved in programmed necrotic cell death IMP
IMP: Inferred from mutant phenotype
23666923 GOA
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
23666923 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALKBH7 Protein Structure

2OG-FeII_Oxy_2

2OG-FeII_Oxy_2: 2OG-Fe(II) oxygenase superfamily (75 - 199)

  • 0
  • 100
  • 200
  • 221 a.a.
Protein Preferred Names Protein Names

alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial

alkB, alkylation repair homolog 7

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00608 ALKBH7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ALKBH7 VGNC VGNC:69663
Canis familiaris ALKBH7 VGNC VGNC:37807
Bos taurus ALKBH7 VGNC VGNC:25838
Felis catus ALKBH7 VGNC VGNC:59753
Rattus norvegicus ALKBH7 RGD RGD:1598126
Mus musculus ALKBH7 MGD MGI:1913650