NTPCR - nucleoside-triphosphatase, cancer-related Gene

Homo sapiens

Also known as THEP1; C1orf57; HCR-NTPase

Gene ID: 84284 | Gene type: protein coding

About NTPCR

This gene has 8 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in brain (RPKM 18.5), kidney (RPKM 18.3) and 25 other tissues.

Summary

The protein encoded by this gene is a non-specific nucleoside triphosphatase that is slow-acting in vitro. This gene is overexpressed in many tumor tissues, and while it is not essential for the cell, overexpression is cytotoxic. However, the cytotoxicity is not related to its triphosphatase activity. [provided by RefSeq, Jul 2016]

NTPCR Products(3)

mRNA	Protein	Name
NM_001329452.2	NP_001316381.1	cancer-related nucleoside-triphosphatase isoform 2
NM_001329453.2	NP_001316382.1	cancer-related nucleoside-triphosphatase isoform 3
NM_032324.3	NP_115700.1	cancer-related nucleoside-triphosphatase isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables ribonucleoside triphosphate phosphatase activity	IMP IMP: Inferred from mutant phenotype	17291528	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NTPCR Protein Structure

NTPase_1

0
100
190 a.a.

Protein Preferred Names

Protein Names

cancer-related nucleoside-triphosphatase

human cancer-related NTPase

NTPCR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81699	NTPCR Antibody (YA1444)	WB, IP	Human

Related Diseases

Diseases

Alias

Blackwater Fever

Black Water Fever	Hemoglobinuric, Malaria
Malarial Hemoglobinuria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09627	NTPCR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NTPCR	RGD	RGD:1306192
Mus musculus	NTPCR	MGD	MGI:1913816

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