DDI2 - DNA damage inducible 1 homolog 2 Gene

Homo sapiens

Gene ID: 84301 | Gene type: protein coding

About DDI2

This gene has 6 transcripts (splice variants), 164 orthologues and 4 paralogues. Ubiquitous expression in esophagus (RPKM 7.7), kidney (RPKM 5.8) and 25 other tissues.

Summary

Enables aspartic-type endopeptidase activity; identical protein binding activity; and ubiquitin binding activity. Involved in several processes, including cellular response to hydroxyurea; proteolysis; and regulation of DNA stability. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DDI2 Products(1)

mRNA	Protein	Name
NM_032341.5	NP_115717.3	protein DDI1 homolog 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables aspartic-type endopeptidase activity	IDA IDA: Inferred from direct assay	27528193	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	27461074	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	27528193	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	27461074	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hydroxyurea	IMP IMP: Inferred from mutant phenotype	29290612	GOA
involved in proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	29290612	GOA
involved in protein processing	IDA IDA: Inferred from direct assay	27528193	GOA
involved in protein processing	IMP IMP: Inferred from mutant phenotype	27676298	GOA
involved in regulation of DNA stability	IMP IMP: Inferred from mutant phenotype	29290612	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	29290612	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDI2 Protein Structure

ubiquitin

Asp_protease

0
100
200
300
399 a.a.

Protein Preferred Names

Protein Names

protein DDI1 homolog 2

DDI1, DNA-damage inducible 1, homolog 2

Related Diseases

Diseases

Alias

Ngly1-Deficiency

Deficiency Of N-Glycanase 1	Ngly1-Cddg
Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome	Ngly1 Deficiency
Congenital Disorder Of Deglycosylation	Congenital Disorder Of Glycosylation Type Iv
Congenital Disorder Of Deglycosylation	Cddg
Congenital Disorder Of Glycosylation Type Iv	Cdg1v

Ruijs-Aalfs Syndrome

Progeroid Features-Hepatocellular Carcinoma Predisposition Syndrome

RJALS

Combat Disorder

Combat Disorders

Combat Neurosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03612	DDI2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DDI2	MGD	MGI:1917244
Rattus norvegicus	DDI2	RGD	RGD:1311815
Canis familiaris	DDI2	VGNC	VGNC:52126

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