2. Gene
  3. THOC3 - THO complex subunit 3 Gene

THOC3 - THO complex subunit 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as THO3; hTREX45

Gene ID: 84321 | Gene type: protein coding

About THOC3

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:175,959,531-175,968,315 (from NCBI)

This gene has 12 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in esophagus (RPKM 29.0), testis (RPKM 21.2) and 24 other tissues.

Summary

This gene encodes a component of the nuclear THO transcription elongation complex, which is part of the larger transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the transcription export complex is recruited to the 5'-end of messenger RNAs in a splicing- and cap-dependent manner. Studies of a related complex in mouse suggest that the metazoan transcription export complex is involved in cell differentiation and development. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, May 2013]

THOC3 Products(2)

mRNA Protein Name
NM_001376902.1 NP_001363831.1 THO complex subunit 3 isoform 2
NM_032361.4 NP_115737.1 THO complex subunit 3 isoform 1

THOC3 Protein Structure

WD40

WD40: WD domain, G-beta repeat (48 - 81)

WD40

WD40: WD domain, G-beta repeat (95 - 128)

PD40

PD40: WD40-like Beta Propeller Repeat (138 - 157)

WD40

WD40: WD domain, G-beta repeat (215 - 252)

WD40

WD40: WD domain, G-beta repeat (268 - 290)

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  • 351 a.a.
Protein Preferred Names Protein Names

THO complex subunit 3

TEX1 homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14493 THOC3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris THOC3 VGNC VGNC:47350
Mus musculus THOC3 MGD MGI:1920916
Macaca mulatta THOC3 VGNC VGNC:79176
Rattus norvegicus THOC3 RGD RGD:1311669
Bos taurus THOC3 VGNC VGNC:58351