BRSK1 - BR serine/threonine kinase 1 Gene

Homo sapiens

Also known as SAD-B; hSAD1

Gene ID: 84446 | Gene type: protein coding

About BRSK1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,283,997-55,312,562 (from NCBI)

This gene has 8 transcripts (splice variants), 131 orthologues and 17 paralogues. Biased expression in brain (RPKM 29.2), adrenal (RPKM 3.5) and 4 other tissues.

Summary

Enables magnesium ion binding activity; protein serine/threonine kinase activity; and tau-protein kinase activity. Involved in mitotic G2 DNA damage checkpoint signaling and protein phosphorylation. Acts upstream of or within G2/M transition of mitotic cell cycle; peptidyl-serine phosphorylation; and response to UV. Located in cell junction; cytoplasm; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

BRSK1 Products(1)

mRNA	Protein	Name
NM_032430.2	NP_115806.1	serine/threonine-protein kinase BRSK1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables magnesium ion binding	IDA IDA: Inferred from direct assay	14976552	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	15150265	GOA
enables tau-protein kinase activity	IDA IDA: Inferred from direct assay	21985311	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	15150265	GOA
acts upstream of or within G2/M transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	15150265	GOA
involved in mitotic G2 DNA damage checkpoint signaling	IDA IDA: Inferred from direct assay	15150265	GOA
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	15150265	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	15150265	GOA
acts upstream of or within response to UV	IDA IDA: Inferred from direct assay	15150265	GOA
involved in response to UV	IDA IDA: Inferred from direct assay	15150265	GOA
NOT involved in response to ionizing radiation	IDA IDA: Inferred from direct assay	15150265	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15150265	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15150265	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRSK1 Protein Structure

Pkinase

0
200
400
600
778 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase BRSK1

BR serine/threonine-protein kinase 1

Related Diseases

Diseases

Alias

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01637	BRSK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BRSK1	MGD	MGI:2685946
Macaca mulatta	BRSK1	VGNC	VGNC:70345
Bos taurus	BRSK1	VGNC	VGNC:50055
Rattus norvegicus	BRSK1	RGD	RGD:1563268
Felis catus	BRSK1	VGNC	VGNC:60184
Canis familiaris	BRSK1	VGNC	VGNC:53668
Others	BRSK1	NCBI

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