2. Gene
  3. DUSP11 - dual specificity phosphatase 11 Gene

DUSP11 - dual specificity phosphatase 11 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as PIR1

Gene ID: 8446 | Gene type: protein coding

About DUSP11

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:73,762,213-73,780,103 (from NCBI)

This gene has 13 transcripts (splice variants), 219 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 14.8), urinary bladder (RPKM 12.3) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the dual specificity protein Phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]

DUSP11 Products(1)

mRNA Protein Name
NM_003584.3 NP_003575.3 RNA/RNP complex-1-interacting phosphatase
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA binding IDA
IDA: Inferred from direct assay
9685386 GOA
enables phosphatase activity IDA
IDA: Inferred from direct assay
24447265 GOA
enables polynucleotide 5'-phosphatase activity IDA
IDA: Inferred from direct assay
10347225 GOA
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
9685386 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein dephosphorylation IDA
IDA: Inferred from direct assay
9685386 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nuclear speck IDA
IDA: Inferred from direct assay
9685386 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DUSP11 Protein Structure

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (166 - 247)

  • 0
  • 100
  • 200
  • 300
  • 377 a.a.
Protein Preferred Names Protein Names

RNA/RNP complex-1-interacting phosphatase

RNA/RNP complex 1-interacting

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04052 DUSP11 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DUSP11 VGNC VGNC:72011
Canis familiaris DUSP11 VGNC VGNC:40127
Felis catus DUSP11 VGNC VGNC:61660
Mus musculus DUSP11 MGD MGI:1919352
Bos taurus DUSP11 VGNC VGNC:28250
Rattus norvegicus DUSP11 RGD RGD:1307038