2. Gene
  3. MEGF10 - multiple EGF like domains 10 Gene

MEGF10 - multiple EGF like domains 10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SR-F3; EMARDD

Gene ID: 84466 | Gene type: protein coding

About MEGF10

Cytogenetic location: 5q23.2 Genomic coordinates (GRCh38): 5:127,229,300-127,461,222 (from NCBI)

This gene has 10 transcripts (splice variants), 193 orthologues, 3 paralogues and is associated with 3 phenotypes. Biased expression in brain (RPKM 5.7), adrenal (RPKM 1.0) and 4 other tissues.

Summary

This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012]

MEGF10 Products(4)

mRNA Protein Name
NM_001256545.2 NP_001243474.1 multiple epidermal growth factor-like domains protein 10 isoform a precursor
NM_001308119.2 NP_001295048.1 multiple epidermal growth factor-like domains protein 10 isoform b precursor
NM_001308121.2 NP_001295050.1 multiple epidermal growth factor-like domains protein 10 isoform b precursor
NM_032446.3 NP_115822.1 multiple epidermal growth factor-like domains protein 10 isoform a precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables Notch binding IPI
IPI: Inferred from physical interaction
28498977 GOA
enables complement component C1q complex binding IDA
IDA: Inferred from direct assay
27170117 GOA
enables scavenger receptor activity IDA
IDA: Inferred from direct assay
27170117 GOA
Biological Process GO Annotation Evidence Reference Source
involved in homotypic cell-cell adhesion IDA
IDA: Inferred from direct assay
22407321 GOA
involved in muscle cell development IMP
IMP: Inferred from mutant phenotype
22101682 GOA
involved in muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
28498977 GOA
involved in myoblast migration IMP
IMP: Inferred from mutant phenotype
28498977 GOA
involved in positive regulation of cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
31267131 GOA
involved in positive regulation of myoblast proliferation IMP
IMP: Inferred from mutant phenotype
31267131 GOA
involved in regulation of muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
22101682 GOA
involved in regulation of skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
22101682 GOA
involved in skeletal muscle satellite cell differentiation IMP
IMP: Inferred from mutant phenotype
22101682 GOA
Cellular Component GO Annotation Evidence Reference Source
located in phagocytic cup IDA
IDA: Inferred from direct assay
17205124 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
27170117 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MEGF10 Protein Structure

hEGF

hEGF: Human growth factor-like EGF (209 - 221)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (281 - 319)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (368 - 411)

hEGF

hEGF: Human growth factor-like EGF (557 - 568)

hEGF

hEGF: Human growth factor-like EGF (645 - 656)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (759 - 796)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (802 - 830)

  • 0
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  • 1000
  • 1140 a.a.
Protein Preferred Names Protein Names

multiple epidermal growth factor-like domains protein 10

Recombinant MEGF10 Proteins

Cat. No. Product Name Accession Purity
HY-P76490 MEGF10 Protein, Human (HEK293, Fc) Q96KG7-1 (L26-G857) ≥95%
HY-P76491 MEGF10 Protein, Human (HEK293, His) Q96KG7-1 L26-G857) ≥95%

Related Diseases

Diseases Alias
Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset

EMARDD

Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset, Mild Variant

Early-Onset Myopathy-Areflexia-Respiratory Distress-Dysphagia Syndrome

Early-Onset Myopathy, Areflexia, Respiratory Distress And Dysphagia

Myopathy, Early-Onset, Areflexia, Respiratory Distress, And Dysphagia
Myopathy

Muscular Diseases

Myopathies
Scoliosis
Rhabdomyolysis-Myalgia Syndrome
Respiratory Failure

Acute Respiratory Failure

Chronic Respiratory Failure

Respiratory Insufficiency

Acute-On-Chronic Respiratory Failure

Respiratory Disease

Acute And Chronic Respiratory Failure

Respiratory Insufficiency/Failure

Chronic Respiratory Disease

Pulmonary Valve Insufficiency

Chronic Disease Of Respiratory System

Respiration Disorders

Respiratory Tract Diseases

Lung Failure Nos

Pulmonary Failure

Arf - [Acute Respiratory Failure]

Acute Respiratory Insufficiency

Acute Pulmonary Insufficiency

Acute Respiration Failure

Chronic Respiration Failure
Multiminicore Disease

Multiminicore Myopathy

Mmd

Minicore Disease

Minicore Myopathy

Multi-Core Congenital Myopathy

Multi-Core Disease

Multi-Minicore Disease

Multicore Disease

Multicore Myopathy

Minicore Myopathy With External Ophthalmoplegia
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Cortical Dysplasia, Complex, With Other Brain Malformations 6

Complex Cortical Dysplasia With Other Brain Malformations 6

CDCBM6

Cdcbm56

Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 6
Nemaline Myopathy 2

NEM2

Nemaline Myopathy 2, Autosomal Recessive

Nemaline Myopathy, Type 2

Neb-Related Nemaline Myopathy

Myopathy, Nemaline, Type 2
Batten-Turner Congenital Myopathy

Congenital Myopathy

Batten Turner Congenital Myopathy

Myopathy Congenital

Myopathy, Congenital

Myotonia Congenita

Benign Congenital Myopathy
Congenital Fiber-Type Disproportion

Congenital Fiber Type Disproportion

Cftdm

Congenital Myopathy With Fiber Type Disproportion

Cftd

Congenital Fiber-Type Disproportion Myopathy

Fiber-Type Disproportion Myopathy, Congenital

Myopathy, Congenital With Fiber-Type Disproportion
Rigid Spine Muscular Dystrophy 1

Rigid Spine Syndrome

RSMD1

Rss

Mdrs1

Eichsfeld Type Congenital Muscular Dystrophy

Desmin-Related Myopathy With Mallory Bodies

Classic Multiminicore Myopathy

Sepn1-Related Myopathy

Multicore Myopathy, Severe Classic Form

Minicore Myopathy, Severe Classic Form

Multiminicore Disease, Severe Classic Form

Muscular Dystrophy, Rigid Spine, 1

Classic Mmd

Classic Multiminicore Disease

Congenital Merosin-Positive Muscular Dystrophy With Early Spine Rigidity

Desmin-Related Myopathy With Mallory Body-Like Inclusions

Early-Onset Desmin-Related Myopathy

Myopathy, Sepn1-Related

Muscular Dystrophy, Congenital, Merosin-Positive, With Early Spine Rigidity

Muscular Dystrophy, Congenital, Eichsfeld Type

Severe Classic Form Minicore Myopathy

Severe Classic Form Multicore Myopathy

Severe Classic Form Multiminicore Disease

Desmin-Related Myopathies With Mallory Bodies

Muscular Dystrophy, Congenital, Merosin Positive With Early Spine Rigidity

Rigid Spine Muscular Dystrophy-1

Rigid Spine Congenital Muscular Dystrophy

Congenital Muscular Dystrophy Eichsfeld Type

Congenital Muscular Dystrophy Merosin-Positive With Early Spine Rigidity

Minicore Myopathy Severe Classic Form

Multicore Myopathy Severe Classic Form

Multiminicore Disease Severe Classic Form

Dystrophy, Muscular, Rigid Spine, Type 1
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08314 MEGF10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MEGF10 VGNC VGNC:74617
Bos taurus MEGF10 VGNC VGNC:31375
Canis familiaris MEGF10 VGNC VGNC:43147
Felis catus MEGF10 VGNC VGNC:102255
Mus musculus MEGF10 MGD MGI:2685177
Rattus norvegicus MEGF10 RGD RGD:735084
Others MEGF10 NCBI