SPIRE2 - spire type actin nucleation factor 2 Gene

Homo sapiens

Also known as Spir-2

Gene ID: 84501 | Gene type: protein coding

About SPIRE2

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:89,828,475-89,871,319 (from NCBI)

This gene has 10 transcripts (splice variants), 198 orthologues and 1 paralogue. Broad expression in stomach (RPKM 4.5), colon (RPKM 4.1) and 20 other tissues.

Summary

Predicted to enable actin binding activity. Involved in establishment of meiotic spindle localization; formin-nucleated actin cable assembly; and positive regulation of double-strand break repair. Predicted to be located in cytoskeleton; cytosol; and plasma membrane. Predicted to be active in cell cortex and cytoplasmic vesicle membrane. Predicted to colocalize with cleavage furrow. [provided by Alliance of Genome Resources, Apr 2022]

SPIRE2 Products(1)

mRNA	Protein	Name
NM_032451.2	NP_115827.1	protein spire homolog 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21620703	GOA
involved in establishment of meiotic spindle localization	IMP IMP: Inferred from mutant phenotype	21620703	GOA
involved in formin-nucleated actin cable assembly	IMP IMP: Inferred from mutant phenotype	26287480	GOA
involved in positive regulation of double-strand break repair	IMP IMP: Inferred from mutant phenotype	26287480	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein spire homolog 2

spire actin nucleation factor 2

Related Diseases

Diseases

Alias

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Familial Hypercholesterolemia

Hyperlipoproteinemia Type Iia	Familial Hyperbetalipoproteinaemia
Familial Hypercholesteremia	Fredrickson Type Iia Hyperlipoproteinemia
Fredrickson Type Iia Lipidaemia	Hyperbetalipoproteinemia
Type Ii Hyperlipidemia	Familial Hypercholesterolæmia
Familial Hypercholesterolaemia	Fh
Hypercholesterolemia Familial	Hyperlipoproteinemia Type Ii
Hypercholesterolemia, Familial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13688	SPIRE2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-161011	Spire2-FMN2 interaction-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SPIRE2	MGD	MGI:2446256
Felis catus	SPIRE2	VGNC	VGNC:65641
Macaca mulatta	SPIRE2	VGNC	VGNC:78023
Canis familiaris	SPIRE2	VGNC	VGNC:46749
Bos taurus	SPIRE2	VGNC	VGNC:35223
Rattus norvegicus	SPIRE2	RGD	RGD:1305837

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