Hamp - hepcidin antimicrobial peptide Gene

Mus musculus

Also known as Hepc; Hamp1; Hepc1

Gene ID: 84506 | Gene type: protein coding

About Hamp

Summary

This gene encodes hepcidin, an antimicrobial peptide and master hormonal regulator of systemic iron metabolism. The encoded preproprotein is synthesized in the hepatocytes where it undergoes proteolytic processing to generate disulfide-linked mature Peptides that are secreted into the bloodstream. Mice lacking the encoded protein develop multivisceral iron overlaod, with sparing of the spleen macrophages. Certain mutations in the human ortholog of this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis. This gene is located adjacent to a related hepcidin gene on chromosome 7. [provided by RefSeq, Aug 2016]

Hamp Products(1)

mRNA	Protein	Name
NM_032541.2	NP_115930.1	hepcidin preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables copper ion binding	IDA IDA: Inferred from direct assay	20113314	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	20530874	MGI
acts upstream of or within defense response to bacterium	IDA IDA: Inferred from direct assay	11113131	MGI
acts upstream of or within defense response to bacterium	IMP IMP: Inferred from mutant phenotype	23390527	MGI
acts upstream of or within defense response to fungus	IDA IDA: Inferred from direct assay	2995362	MGI
acts upstream of establishment of localization in cell	IGI IGI: Inferred from genetic interaction	21700773	MGI
acts upstream of inflammatory response	IGI IGI: Inferred from genetic interaction	20530874	MGI
involved in intracellular iron ion homeostasis	IDA IDA: Inferred from direct assay	11447267	MGI
acts upstream of iron ion transmembrane transport	IGI IGI: Inferred from genetic interaction	21700773	MGI
acts upstream of macrophage activation	IMP IMP: Inferred from mutant phenotype	22383698	MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis	IDA IDA: Inferred from direct assay	20113314	MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	16574947	MGI
acts upstream of or within myeloid cell homeostasis	IMP IMP: Inferred from mutant phenotype	24357729	MGI
acts upstream of or within negative regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	24561287	MGI
acts upstream of or within negative regulation of inflammatory response	IGI IGI: Inferred from genetic interaction	20530874	MGI
acts upstream of or within negative regulation of iron ion transmembrane transport	IGI IGI: Inferred from genetic interaction	21700773	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18539898	MGI
acts upstream of or within positive regulation of macrophage activation	IMP IMP: Inferred from mutant phenotype	22383698	MGI
acts upstream of or within positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	21700773	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	18800028	MGI
acts upstream of protein catabolic process	IDA IDA: Inferred from direct assay	21700773	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	18800028	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	11447267	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	17435114	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11113132	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hepcidin

hepcidin antimicrobial peptide 1

Recombinant Hamp Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700634	Hepcidin/HAMP Protein, Mouse (GST)	Q9EQ21 (D59-T83)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05995	HAMP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hamp	NCBI	NCBI:57817

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