ATRN - attractin Gene

Homo sapiens

Also known as MGCA; DPPT-L

Gene ID: 8455 | Gene type: protein coding

About ATRN

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,471,018-3,651,118 (from NCBI)

This gene has 2 transcripts (splice variants), 209 orthologues and 27 paralogues. Ubiquitous expression in duodenum (RPKM 20.8), thyroid (RPKM 17.2) and 25 other tissues.

Summary

This gene encodes both membrane-bound and secreted protein isoforms. A membrane-bound isoform exhibits sequence similarity with the mouse mahogany protein, a receptor involved in controlling obesity. A secreted isoform is involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines. [provided by RefSeq, Apr 2016]

ATRN Products(4)

mRNA	Protein	Name
NM_001207047.3	NP_001193976.1	attractin isoform 4
NM_001323332.2	NP_001310261.1	attractin isoform 5 precursor
NM_139321.3	NP_647537.1	attractin isoform 1 preproprotein
NM_139322.4	NP_647538.1	attractin isoform 2 preproprotein

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	17261078	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATRN Protein Structure

CUB

Kelch_1

Kelch_4

Lectin_C

PSI

0
300
600
900
1200
1429 a.a.

Protein Preferred Names

Protein Names

attractin

attractin-2

Related Diseases

Diseases

Alias

Kidney Cortex Necrosis

Renal Cortical Necrosis

Seborrheic Dermatitis

Seborrhoeic Dermatitis	Seborrhea
Seborrhoeic Eczema	Skin Seborrheic
Dermatitis, Seborrheic

External Ear Disease

Diseases Of External Ear	Preauricular Cyst
Preauricular Sinus And Fistula	Preauricular Sinus Or Fistula

Otitis Externa

Swimmer'S Ear	Infective Otitis Externa
Acute Infective Otitis Externa

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01250	ATRN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ATRN	VGNC	VGNC:68790
Macaca mulatta	ATRN	VGNC	VGNC:70194
Rattus norvegicus	ATRN	RGD	RGD:69063
Canis familiaris	ATRN	VGNC	VGNC:38295
Bos taurus	ATRN	VGNC	VGNC:26335
Mus musculus	ATRN	MGD	MGI:1341628

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