2. Gene
  3. SLC12A8 - solute carrier family 12 member 8 Gene

SLC12A8 - solute carrier family 12 member 8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CCC9

Gene ID: 84561 | Gene type: protein coding

About SLC12A8

Cytogenetic location: 3q21.2 Genomic coordinates (GRCh38): 3:125,082,644-125,212,748 (from NCBI)

This gene has 16 transcripts (splice variants), 191 orthologues and 8 paralogues. Broad expression in thyroid (RPKM 11.6), gall bladder (RPKM 6.0) and 17 other tissues.

Summary

This gene is thought to be a candidate for psoriasis susceptibility. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2010]

SLC12A8 Products(2)

mRNA Protein Name
NM_001195483.2 NP_001182412.2 solute carrier family 12 member 8
NM_024628.6 NP_078904.4 solute carrier family 12 member 8
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC12A8 Protein Structure

AA_permease

AA_permease: Amino acid permease (44 - 411)

  • 0
  • 200
  • 400
  • 600
  • 714 a.a.
Protein Preferred Names Protein Names

solute carrier family 12 member 8

cation-chloride cotransporter 9

SLC12A8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SLC12A8 A0AV02 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
SLC12A8 A0AV02 PAX6 Homo sapiens P26367
Validated Y2H
32296183
Intra
SLC12A8 A0AV02 PAX6 Homo sapiens P26367
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Psoriasis
Psoriasis 6

PSORS6

Psoriasis Susceptibility 6

Psoriasis 6, Susceptibility To
Psoriasis 8

PSORS8

Psoriasis Susceptibility 8

Psoriasis 8, Susceptibility To
Psoriasis 9

PSORS9

Psoriasis 9, Susceptibility To

Psoriasis Susceptibility 9
Psoriasis 10

PSORS10

Psoriasis Susceptibility 10

Psoriasis 10, Susceptibility To
Psoriasis 7

PSORS7

Psoriasis 7, Susceptibility To

Psoriasis Susceptibility 7

Psoriasis

Psoriasis Vulgaris

Pv
Corneal Abscess
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13003 SLC12A8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SLC12A8 VGNC VGNC:46225
Felis catus SLC12A8 VGNC VGNC:65194
Mus musculus SLC12A8 MGD MGI:2443672
Rattus norvegicus SLC12A8 RGD RGD:628730
Bos taurus SLC12A8 VGNC VGNC:34671
Macaca mulatta SLC12A8 VGNC VGNC:84080