NT5C1A - 5'-nucleotidase, cytosolic IA Gene

Homo sapiens

Also known as CN1; CNI; CN-I; CN1A; CN-IA

Gene ID: 84618 | Gene type: protein coding

About NT5C1A

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:39,651,229-39,672,107 (from NCBI)

This gene has 1 transcript (splice variant), 269 orthologues and 1 paralogue. Biased expression in heart (RPKM 3.5), brain (RPKM 1.5) and 5 other tissues.

Summary

Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 [PubMed 11133996]).[supplied by OMIM, Mar 2008]

NT5C1A Products(1)

mRNA	Protein	Name
NM_032526.3	NP_115915.1	cytosolic 5'-nucleotidase 1A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 5'-nucleotidase activity	IDA IDA: Inferred from direct assay	599155	GOA
enables IMP 5'-nucleotidase activity	IDA IDA: Inferred from direct assay	11133996	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	8967393	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in AMP catabolic process	IDA IDA: Inferred from direct assay	11133996	GOA
involved in IMP catabolic process	IDA IDA: Inferred from direct assay	11133996	GOA
involved in allantoin metabolic process	IDA IDA: Inferred from direct assay	11133996	GOA
involved in dAMP catabolic process	IDA IDA: Inferred from direct assay	11133996	GOA
involved in dGMP catabolic process	IDA IDA: Inferred from direct assay	11133996	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytosol	IDA IDA: Inferred from direct assay	11133996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NT5C1A Protein Structure

5-nucleotidase

0
100
200
300
368 a.a.

Protein Preferred Names

Protein Names

cytosolic 5'-nucleotidase 1A

AMP-specific 5'-NT

NT5C1A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NT5C1A	Q9BXI3	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	25416956
Intra	NT5C1A	Q9BXI3	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Granulomatous Myositis

Myositis

Idiopathic Inflammatory Myopathy	Idiopathic Inflammatory Myositis
Iim	Imm
Idiopathic Inflammatory Myopathies	Myopathy, Familial Idiopathic Inflammatory
Inflammatory Disorder Of Muscle	Idiopathic Inflammatory Myopathy, Familial
Inflammatory Myopathy, Idiopathic	Myopathies Idiopathic Inflammatory
Familial Idiopathic Inflammatory Myopathy

Anal Canal Adenocarcinoma

Adenocarcinoma Of The Anal Canal

Adenocarcinoma Of Anal Canal

Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone With Or Without Frontotemporal Dementia 2

Ibmpfd2	Msp2
Multisystem Proteinopathy 2

Crigler-Najjar Syndrome, Type I

Crigler-Najjar Syndrome	Crigler-Najjar Syndrome Type 1
Bilirubin Udp Glucuronyl Transferase Deficiency	Crigler Najjar Syndrome
Crigler Najjar Syndrome, Type 1	Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency
Bilirubin-Ugt Deficiency	Hyperbilirubinemia, Crigler-Najjar Type I
Hblrcn1	Familial Nonhemolytic Unconjugated Hyperbilirubinemia
Hereditary Unconjugated Hyperbilirubinemia	Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1
Bilirubin-Ugt Deficiency Type 1	Crigler-Najjar Syndrome 1
CN1	Cn-I
Crigler-Najjar Syndrome Type I	Hereditary Unconjugated Hyperbilirubinaemia
Ugt Deficiency	Bilirubin Glucuronosyltransferase Deficiency
Crigler-Najjar Disease Or Syndrome	Deficiency Of Glucuronosyltransferase
Glucuronyl Transferase Deficiency	Glucuronyltransferase Deficiency
Udp Glucuronyl Transferase Deficiency	Cns - [Crigler-Najjar Syndrome]
Congenital Familial Nonhemolytic Jaundice

Antisynthetase Syndrome

As Syndrome

Anti-Jo1 Syndrome

Kernicterus

Bilirubin Encephalopathy	Hyperbilirubinemic Encephalopathy
Kernicterus Spectrum Disorder

Childhood Type Dermatomyositis

Juvenile Dermatomyositis	Juvenile Dm
Childhood Dermatomyositis	Amyopathic Dermatomyositis
Adm	Dermatomyositis Sine Myositis
Dermatomyositis, Childhood Type

Postpoliomyelitis Syndrome

Postpolio Syndrome	Post-Polio Syndrome
Post Polio Syndrome	Polio Late Effects
Post-Polio Muscular Atrophy	Post-Polio Sequelae
Post-Poliomyelitic Syndrome	Postpolio Sequelae
Postpoliomyelitic Syndrome	Postpoliomyelitis Sequelae

Adult Dermatomyositis

Adult Onset Dermatomyositis

Adult Type Dermatomyositis

Gilbert Syndrome

Gilbert Disease	Gilbert'S Disease
Gilbert'S Syndrome	Cholemia, Familial
Familial Nonhemolytic Jaundice	Meulengracht Syndrome
Gilbert Syndrome, Susceptibility To	Hyperbilirubinemia, Gilbert Type
Hblrg	Hyperbilirubinemia, Arias Type
Hyperbilirubinemia I	Constitutional Hyperbilirubinemia
Gilbert-Meulengracht Syndrome	Hereditary Nonhemolytic Jaundice
Hyperbilirubinemia Arias Type	Hyperbilirubinemia Type 1
Constitutional Liver Dysfunction	Gilbert-Lereboullet Syndrome
Hyperbilirubinemia 1	Unconjugated Benign Bilirubinemia
GILBS	Gilberts Syndrome
Familial Nonhaemolytic Jaundice	Constitutional Hyperbilirubinaemia
Hereditary Nonhaemolytic Bilirubinaemia	Familial Nonhaemolytic Bilirubinaemia
Idiopathic Hyperbilirubinaemia	Icterus Intermittens Juvenilis
Chronic Intermittent Juvenile Jaundice	Low-Grade Chronic Hyperbilirubinaemia Syndrome
Benign Unconjugated Bilirubinaemia Syndrome	Hereditary Nonhaemolytic Jaundice
Idiopathic Unconjugated Hyperbilirubinaemia	Gilbert--Lereboullet Syndrome
Constitutional Hepatic Dysfunction	Meulengracht Icterus
Cholaemia Familiaris Simplex	Familial Cholaemia
Congenital Familial Cholaemia	Physiologic Cholaemia
Hyperbilirubinaemia Type 1	Gilbert Cholaemia

Bilirubin Metabolic Disorder

Hyperbilirubinemia	Hereditary Hyperbilirubinemia
Hyperbilirubinemia, Hereditary	Hyperbilirubinaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09608	NT5C1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NT5C1A	VGNC	VGNC:32290
Rattus norvegicus	NT5C1A	RGD	RGD:1310908
Macaca mulatta	NT5C1A	VGNC	VGNC:106419
Felis catus	NT5C1A	VGNC	VGNC:63897
Mus musculus	NT5C1A	MGD	MGI:2155700
Canis familiaris	NT5C1A	VGNC	VGNC:43995

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