NTNG2 - netrin G2 Gene

Homo sapiens

Also known as Lmnt2; NTNG1; NEDBASH; LHLL9381; bA479K20.1

Gene ID: 84628 | Gene type: protein coding

About NTNG2

Cytogenetic location: 9q34.13 Genomic coordinates (GRCh38): 9:132,161,689-132,244,526 (from NCBI)

This gene has 3 transcripts (splice variants), 282 orthologues, 27 paralogues and is associated with 3 phenotypes. Biased expression in bone marrow (RPKM 7.5), brain (RPKM 4.1) and 4 other tissues.

Summary

Predicted to be involved in several processes, including basement membrane assembly; cell morphogenesis involved in differentiation; and regulation of cell projection organization. Located in Flemming body; intercellular bridge; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

NTNG2 Products(1)

mRNA	Protein	Name
NM_032536.4	NP_115925.2	netrin-G2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21946559	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NTNG2 Protein Structure

Laminin_N

Laminin_EGF

0
100
200
300
400
500
530 a.a.

Protein Preferred Names

Protein Names

netrin-G2

laminet 2

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder With Behavioral Abnormalities, Absent Speech, And Hypotonia

NEDBASH

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Bruxism

Sleep Bruxism	Sleep-Related Bruxism
Bruxism - Teeth Grinding	Grinding Teeth
Sleep Related Bruxism	Teeth Grinding
Sleep Related Teeth Grinding

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Rett Syndrome

Atypical Rett Syndrome	RTT
Rett Disorder	Rts
Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use	Rett Syndrome, Preserved Speech Variant
Rett Syndrome, Atypical	Rett'S Disorder
Rett Syndrome Variant	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Cerebroatrophic Hyperammonemia	Rett Like Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Schizophrenia 12

Sczd12

Schizophrenia Susceptibility Locus, Chromosome 1p-Related

Partial Fetal Alcohol Syndrome

Hypotonia

St. Louis Encephalitis

Saint Louis Encephalitis	Neuroinvasive St. Louis Encephalitis Virus Infection
Encephalitis, St. Louis	Neuroinvasive Saint Louis Encephalitis Virus Infection
St. Louis Encephalitis Virus Infection	St. Louis Encephalitis Virus Neuroinvasive Disease
St. Louis Viral Disease	Type C Lethargic Encephalitis
Encephalitis Type C

Intellectual Developmental Disorder, Autosomal Dominant 41

MRD41	Autosomal Dominant Non-Syndromic Intellectual Disability 41
Mental Retardation, Autosomal Dominant 41	Autosomal Dominant Intellectual Developmental Disorder 41
Autosomal Dominant Mental Retardation 41	Mental Retardation, Autosomal Dominant, Type 41

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09626	NTNG2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NTNG2	RGD	RGD:1307089
Bos taurus	NTNG2	VGNC	VGNC:32308
Felis catus	NTNG2	VGNC	VGNC:63907
Macaca mulatta	NTNG2	VGNC	VGNC:75402
Mus musculus	NTNG2	MGD	MGI:2159341

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