MYO18B - myosin XVIIIB Gene

Homo sapiens

Also known as KFS4

Gene ID: 84700 | Gene type: protein coding

About MYO18B

Cytogenetic location: 22q12.1 Genomic coordinates (GRCh38): 22:25,742,188-26,063,847 (from NCBI)

This gene has 10 transcripts (splice variants), 188 orthologues, 43 paralogues and is associated with 3 phenotypes. Biased expression in heart (RPKM 11.4) and testis (RPKM 1.5).

Summary

The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung Cancer. [provided by RefSeq, Jul 2008]

MYO18B Products(2)

mRNA	Protein	Name
NM_001318245.2	NP_001305174.1	unconventional myosin-XVIIIb isoform 1
NM_032608.7	NP_115997.5	unconventional myosin-XVIIIb isoform 2

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	Reference	Source
part of unconventional myosin complex	IDA IDA: Inferred from direct assay	12547197	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYO18B Protein Structure

Myosin_head

0
400
800
1200
1600
2000
2400
2567 a.a.

Protein Preferred Names

Protein Names

unconventional myosin-XVIIIb

myosin 18B

Related Diseases

Diseases

Alias

Klippel-Feil Syndrome 4, Autosomal Recessive, With Nemaline Myopathy And Facial Dysmorphism

Klippel-Feil Anomaly-Myopathy-Facial Dysmorphism Syndrome	KFS4
Klippel-Feil Syndrome 4, Autosomal Recessive, With Myopathy And Facial Dysmorphism

Klippel-Feil Syndrome

Cervical Vertebral Fusion	Congenital Dystrophia Brevicollis
Cervical Fusion Syndrome	Klippel-Feil Deformity
Autosomal Dominant Klippel-Feil Syndrome	Congenital Synostosis Of Cervical Vertebrae
Klippel-Feil And Turner Syndrome	Klippel-Feil Deformity, Deafness And Facial Asymmetry
Klippel Feil Syndrome	Cervical Vertebral Fusion Syndrome
Dystrophia Brevicollis Congenita	Fusion Of Cervical Vertebrae
Kfs	Klippel-Feil Sequence
Vertebral Cervical Fusion Syndrome	Klippel-Feil Syndrome, Autosomal Dominant
Klippel-Feil Malformation	Isolated Klippel-Feil Syndrome

Klippel-Feil Syndrome 2, Autosomal Recessive

Klippel-Feil Syndrome 2	KFS2
Cervical Vertebral Fusion Autosomal Recessive	Kfs, Autosomal Recessive
Cervical Vertebral Fusion, Autosomal Recessive	Kfs Autosomal Recessive
Klippel-Feil Syndrome, Type 2, Autosomal Recessive	Klippel Feil Syndrome Recessive Type

Klippel-Feil Syndrome 4

Klippel-Feil Syndrome 1, Autosomal Dominant

KFS1	Cervical Vertebral Fusion Autosomal Dominant
Kfs	Cervical Vertebral Fusion, Autosomal Dominant
Cervical Vertebral Fusion Congenital	Congenital Klippel-Feil Segment
Fused Cervical Segments Congenital	Isolated Klippel-Feil Syndrome
Klippel-Feil Malformation	Klippel-Feil Sequence
Klippel-Feil Syndrome, Type 1, Autosomal Dominant	Klippel-Feil Syndrome, Autosomal Dominant

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Dyslexia

Myopathy

Muscular Diseases

Myopathies

Myopathy, Congenital, Bailey-Bloch

Native American Myopathy	Nam
MYPBB	Myopathy, Congenital, Baily-Bloch
Anti-Hmg-Coa Myopathy	Anti-Srp Myopathy
Autoimmune Necrotizing Myositis	Imnm
Immune Myopathy With Myocyte Necrosis	Immune-Mediated Necrotizing Myopathy
Myopathy, Congenital, With Myopathic Facies, Scoliosis, And Malignant Hyperthermia	Necrotizing Autoimmune Myopathy
Congenital Myopathy-Cleft Palate-Malignant Hyperthermia Syndrome	Congenital Myopathy With Cleft Palate And Malignant Hyperthermia

Dyscalculia

Disorder Of Arithmetical Skills	Mathematics Disorder
Developmental Arithmetic Disorder

Congenital Structural Myopathy

Multiple Pterygium Syndrome, Escobar Variant

Multiple Pterygium Syndrome	Pterygium
Escobar Syndrome	EVMPS
Pterygium Syndrome	Autosomal Recessive Multiple Pterygium Syndrome
Pterygium Colli Syndrome	Pterygium Universale
Autosomal Recessive Non-Lethal Multiple Pterygium Syndrome	Escobar Variant Multiple Pterygium Syndrome
Multiple Pterygium Syndrome, Nonlethal Type	Surfer'S Eye
Multiple Pterygium Syndrome Escobar Type	Multiple Pterygium Syndrome Nonlethal Type
Familial Pterygium Syndrome	Pterygium Colli
Multiple Pterygium Syndrome, Non-Lethal Type	Nonlethal Type Multiple Pterygium Syndrome
Pterygium Syndrome, Multiple, Escobar Type	Pterygium Of Eye
Web Eye

Distal Arthrogryposis

Arthrogryposis Multiplex Congenita	Arthrogryposis
Congenital Multiple Arthrogryposis	Congenital Arthromyodysplasia
Fibrous Ankylosis Of Multiple Joints	Guerin-Stern Syndrome
Guérin-Stern Syndrome	Myodystrophia Fetalis Deformans
Otto Syndrome	Rocher-Sheldon Syndrome
Rossi Syndrome	Amc
Multiple Congenital Arthrogryposis	Arthrogryposis Syndrome
Arthrogryposis, Distal	Distal Arthrogryposis Syndrome
Freeman-Sheldon Syndrome	Arthrogryposis, Distal, Type 2b
Congenital Multiplex Arthrogryposis	Amyoplasia Congenita
Congenital Amyoplasia	Amc - [Arthrogryposis Multiplex Congenita]

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08935	MYO18B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MYO18B	VGNC	VGNC:82549
Canis familiaris	MYO18B	VGNC	VGNC:43558
Bos taurus	MYO18B	VGNC	VGNC:31814
Macaca mulatta	MYO18B	VGNC	VGNC:74985
Rattus norvegicus	MYO18B	RGD	RGD:1594542
Mus musculus	MYO18B	MGD	MGI:1921626

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