GPAT3 - glycerol-3-phosphate acyltransferase 3 Gene

Homo sapiens

Also known as MAG1; AGPAT8; AGPAT9; AGPAT10; AGPAT 10; HMFN0839; LPAAT-theta

Gene ID: 84803 | Gene type: protein coding

About GPAT3

Cytogenetic location: 4q21.23 Genomic coordinates (GRCh38): 4:83,535,587-83,605,875 (from NCBI)

This gene has 8 transcripts (splice variants), 144 orthologues and 4 paralogues. Broad expression in kidney (RPKM 23.1), duodenum (RPKM 10.2) and 14 other tissues.

Summary

This gene encodes a member of the lysophosphatidic acid Acyltransferase protein family. The encoded protein is an Enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]

GPAT3 Products(3)

mRNA	Protein	Name
NM_001256421.1	NP_001243350.1	glycerol-3-phosphate acyltransferase 3
NM_001256422.1	NP_001243351.1	glycerol-3-phosphate acyltransferase 3
NM_032717.5	NP_116106.2	glycerol-3-phosphate acyltransferase 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	IDA IDA: Inferred from direct assay	19318427	GOA
NOT enables glycerol-3-phosphate O-acyltransferase activity	IDA IDA: Inferred from direct assay	19318427	GOA
enables glycerol-3-phosphate O-acyltransferase activity	IDA IDA: Inferred from direct assay	17170135	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of TOR signaling	IDA IDA: Inferred from direct assay	17002884	GOA
involved in triglyceride biosynthetic process	IDA IDA: Inferred from direct assay	17170135	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	17170135	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	17002884	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPAT3 Protein Structure

Acyltransferase

0
100
200
300
400
434 a.a.

Protein Preferred Names

Protein Names

glycerol-3-phosphate acyltransferase 3

1-AGP acyltransferase 9

Related Diseases

Diseases

Alias

Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy	Berardinelli-Seip Syndrome
Brunzell Syndrome	Bscl
Generalized Lipodystrophy	Lipodystrophy, Congenital Generalized
Seip Syndrome	Total Lipodystrophy
Cgl	Lipoatrophic Diabetes
Lipodystrophy, Generalized, Congenital	Familial Generalized Lipodystrophy
Congenital Generalized Lipodystrophy Type 2	Lipoatrophic Diabetes Mellitus
Familial Partial Lipodystrophy, Type 2

Lipodystrophy, Congenital Generalized, Type 2

Congenital Generalized Lipodystrophy Type 2	CGL2
Berardinelli-Seip Congenital Lipodystrophy Type 2	Berardinelli-Seip Syndrome
Brunzell Syndrome Bscl2-Related	Total Lipodystrophy And Acromegaloid Gigantism
Berardinelli-Seip Congenital Lipodystrophy, Type 2	Seip Syndrome
Berardinelli Syndrome	Lipodystrophy, Total, And Acromegaloid Gigantism
Lipoatrophic Diabetes, Congenital	Lipodystrophy, Berardinelli-Seip Congenital, Type 2
Brunzell Syndrome, Bscl2-Related	Congenital Lipoatrophic Diabetes
Congenital Generalized Lipodystrophy 2	Lipoatrophic Diabetes
Lipodystrophy Berardinelli Type	Familial Generalized Lipodystrophy
Lipoatrophic Diabetes Mellitus	Familial Partial Lipodystrophy, Type 2

Complete Generalized Lipodystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05617	GPAT3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GPAT3	VGNC	VGNC:29513
Canis familiaris	GPAT3	VGNC	VGNC:41363
Felis catus	GPAT3	VGNC	VGNC:62654
Macaca mulatta	GPAT3	VGNC	VGNC:106586
Rattus norvegicus	GPAT3	RGD	RGD:1565703
Mus musculus	GPAT3	MGD	MGI:3603816

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