TRIM52 - tripartite motif containing 52 Gene

Homo sapiens

Also known as RNF102

Gene ID: 84851 | Gene type: protein coding

About TRIM52

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:181,249,062-181,261,143 (from NCBI)

This gene has 10 transcripts (splice variants), 175 orthologues and 80 paralogues. Ubiquitous expression in lymph node (RPKM 9.5), spleen (RPKM 9.1) and 25 other tissues.

Summary

Enables transcription coactivator activity and ubiquitin protein Ligase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; and protein autoubiquitination. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TRIM52 Products(5)

mRNA	Protein	Name
NM_001346048.2	NP_001332977.1	E3 ubiquitin-protein ligase TRIM52 isoform 2
NM_001346049.2	NP_001332978.1	E3 ubiquitin-protein ligase TRIM52 isoform 3
NM_001346050.2	NP_001332979.1	E3 ubiquitin-protein ligase TRIM52 isoform 4
NM_001346051.2	NP_001332980.1	E3 ubiquitin-protein ligase TRIM52 isoform 5
NM_032765.4	NP_116154.1	E3 ubiquitin-protein ligase TRIM52 isoform 1

TRIM52 Protein Structure

zf-C3HC4_4

zf-B_box

0
100
200
297 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase TRIM52

RING finger protein 102

Related Diseases

Diseases

Alias

Japanese Encephalitis

Japanese B Encephalitis	Je
Encephalitis Japanese	Encephalitis, Japanese
Russian Autumnal Encephalitis	Je - [Japanese Encephalitis]
Japanese Encephalitis Virus Disease	Jbe - [Japanese B Encephalitis}
B Type Encephalitis

Encephalitis

Mumps Encephalitis	Mumps Meningoencephalitis
Herpes Simplex Neuroinvasion	Herpetic Encephalitis
Herpetic Encephalopathy	Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis
Encephalitis Due To Herpesviridae	Encephalitis Due To Herpesvirus
Herpes Encephalitis	Herpesviral Encephalitis
Herpes Simplex Encephalitis	Hsv - [Herpes Simplex Virus] Encephalitis
Herpes Virus Encephalitis	Simian B Disease
Simian B Disorder	Encephalitis Nec
Idiopathic Encephalitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15054	TRIM52 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TRIM52	VGNC	VGNC:79172
Mus musculus	TRIM52	MGD	MGI:3045276
Canis familiaris	TRIM52	VGNC	VGNC:59045
Bos taurus	TRIM52	VGNC	VGNC:58617
Rattus norvegicus	TRIM52	RGD	RGD:1565615
Felis catus	TRIM52	VGNC	VGNC:102354

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