ZNF503 - zinc finger protein 503 Gene

Homo sapiens

Also known as Nlz2; NOLZ1; NOLZ-1

Gene ID: 84858 | Gene type: protein coding

About ZNF503

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:75,279,725-75,401,916 (from NCBI)

This gene has 1 transcript (splice variant), 262 orthologues and 1 paralogue. Broad expression in kidney (RPKM 5.4), prostate (RPKM 1.9) and 14 other tissues.

Summary

Predicted to enable metal ion binding activity. Involved in G1 to G0 transition involved in cell differentiation; negative regulation of cell population proliferation; and negative regulation of gene expression. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZNF503 Products(1)

mRNA	Protein	Name
NM_032772.6	NP_116161.2	zinc finger protein 503

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G1 to G0 transition involved in cell differentiation	IDA IDA: Inferred from direct assay	20735826	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	20735826	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	20735826	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF503 Protein Structure

nlz1

0
100
200
300
400
500
600
646 a.a.

Protein Preferred Names

Protein Names

zinc finger protein 503

ZNF503 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZNF503	Q96F45	ATN1	Homo sapiens	Q86V38	Y2H Array	32296183
Intra	ZNF503	Q96F45	ATN1	Homo sapiens	Q86V38	Y2H Prey Pooling	32296183
Intra	ZNF503	Q96F45	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	ZNF503	Q96F45	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	ZNF503	Q96F45	KRTAP19-1	Homo sapiens	Q8IUB9	Y2H Prey Pooling	32296183
Intra	ZNF503	Q96F45	KRTAP19-1	Homo sapiens	Q8IUB9	Y2H Array	32296183
Cross	ZNF503	Q96F45	P0DTD1-PRO_0000449627	SARS-CoV-2	P0DTD1-PRO_0000449627	Y2H Array	36217030
Intra	ZNF503	Q96F45	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Prey Pooling	32296183
Intra	ZNF503	Q96F45	KRTAP3-3	Homo sapiens	Q9BYR6	Validated Y2H	32296183
Intra	ZNF503	Q96F45	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Array	32296183
Intra	ZNF503	Q96F45	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183
Intra	ZNF503	Q96F45	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Fanconi Anemia, Complementation Group B

Fanconi Anemia Complementation Group B	FANCB
Facb	Fa2
Fanconi Pancytopenia Type 2	Fanconi Pancytopenia, Type 2

Coloboma Of Macula

Coloboma	Congenital Ocular Coloboma
Microphthalmia, Isolated, With Coloboma	Agenesis Of Macula
Hereditary Macular Coloboma	Ocular Coloboma
Coloboma Of Eye	Macular Coloboma
Uveoretinal Coloboma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16147	ZNF503 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZNF503	RGD	RGD:1312018
Macaca mulatta	ZNF503	VGNC	VGNC:79398
Bos taurus	ZNF503	VGNC	VGNC:37288
Mus musculus	ZNF503	MGD	MGI:1353644
Felis catus	ZNF503	VGNC	VGNC:67313
Canis familiaris	ZNF503	VGNC	VGNC:48741

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