RSPO3 - R-spondin 3 Gene

Homo sapiens

Also known as PWTSR; THSD2; CRISTIN1

Gene ID: 84870 | Gene type: protein coding

About RSPO3

Cytogenetic location: 6q22.33 Genomic coordinates (GRCh38): 6:127,118,671-127,199,481 (from NCBI)

This gene has 3 transcripts (splice variants), 242 orthologues, 3 paralogues and is associated with 61 phenotypes. Broad expression in endometrium (RPKM 18.7), placenta (RPKM 8.3) and 14 other tissues.

Summary

This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013]

RSPO3 Products(1)

mRNA	Protein	Name
NM_032784.5	NP_116173.2	R-spondin-3 precursor

RSPO3 Protein Structure

TSP_1

0
100
200
272 a.a.

Protein Preferred Names

Protein Names

R-spondin-3

R-spondin 3 homolog

Recombinant RSPO3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70557	RSPO3/R-spondin-3 Protein, Human (HEK293, Fc-His)	Q9BXY4-1 (Q22-V201)	≥95%
HY-P700262	R-spondin 3 Protein, Human (125aa, HEK293, His)	Q9BXY4-1 (Q22-V146)	≥95%

Related Diseases

Diseases

Alias

Tetraamelia Syndrome

Tetra-Amelia Syndrome	Tetraamelia-Multiple Malformations Syndrome
Tetra-Amelia	Tetra-Amelia, Autosomal Recessive
Tetraamelia, Autosomal Recessive	Total Amelia
Zimmer Phocomelia	Tetams
Zimmer Taub Sova Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12307	RSPO3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RSPO3	RGD	RGD:1563246
Felis catus	RSPO3	VGNC	VGNC:64798
Bos taurus	RSPO3	VGNC	VGNC:106906
Mus musculus	RSPO3	MGD	MGI:1920030
Canis familiaris	RSPO3	VGNC	VGNC:49764
Macaca mulatta	RSPO3	VGNC	VGNC:77066
Others	RSPO3	NCBI

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