ATOH8 - atonal bHLH transcription factor 8 Gene

Homo sapiens

Also known as HATH6; bHLHa21

Gene ID: 84913 | Gene type: protein coding

About ATOH8

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:85,753,991-85,791,383 (from NCBI)

This gene has 5 transcripts (splice variants), 175 orthologues and 15 paralogues. Broad expression in fat (RPKM 7.4), lung (RPKM 4.9) and 19 other tissues.

Summary

Enables DNA-binding transcription factor activity and E-box binding activity. Involved in several processes, including SMAD protein signal transduction; positive regulation of endothelial cell differentiation; and regulation of gene expression. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ATOH8 Products(1)

mRNA	Protein	Name
NM_032827.7	NP_116216.2	transcription factor ATOH8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	24236640	GOA
enables E-box binding	IDA IDA: Inferred from direct assay	24236640	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26496921	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	24463812	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	27780851	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	24236640	GOA
involved in positive regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	24236640	GOA
involved in positive regulation of endothelial cell differentiation	IDA IDA: Inferred from direct assay	24463812	GOA
involved in positive regulation of endothelial cell differentiation	IMP IMP: Inferred from mutant phenotype	24463812	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	24463812	GOA
involved in positive regulation of miRNA transcription	IGI IGI: Inferred from genetic interaction	27780851	GOA
involved in tube formation	IMP IMP: Inferred from mutant phenotype	24463812	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	24463812	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATOH8 Protein Structure

HLH

0
100
200
300
321 a.a.

Protein Preferred Names

Protein Names

transcription factor ATOH8

atonal homolog 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01167	ATOH8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ATOH8	VGNC	VGNC:79995
Macaca mulatta	ATOH8	VGNC	VGNC:106131
Rattus norvegicus	ATOH8	RGD	RGD:1561512
Mus musculus	ATOH8	MGD	MGI:1918343
Bos taurus	ATOH8	VGNC	VGNC:26272

Name
Email *

	Sorry, but the email address you supplied was invalid.