TOX2 - TOX high mobility group box family member 2 Gene

Homo sapiens

Also known as GCX1; GCX-1; C20orf100; dJ495O3.1; dJ1108D11.2

Gene ID: 84969 | Gene type: protein coding

About TOX2

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:43,914,852-44,069,616 (from NCBI)

This gene has 6 transcripts (splice variants), 263 orthologues and 20 paralogues. Broad expression in testis (RPKM 5.3), lymph node (RPKM 4.6) and 21 other tissues.

Summary

Enables transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TOX2 Products(4)

mRNA	Protein	Name
NM_001098796.2	NP_001092266.1	TOX high mobility group box family member 2 isoform c
NM_001098797.2	NP_001092267.1	TOX high mobility group box family member 2 isoform a
NM_001098798.2	NP_001092268.1	TOX high mobility group box family member 2 isoform b
NM_032883.3	NP_116272.1	TOX high mobility group box family member 2 isoform c

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	25352127	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	25352127	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOX2 Protein Structure

HMG_box

0
100
200
300
400
488 a.a.

Protein Preferred Names

Protein Names

TOX high mobility group box family member 2

granulosa cell HMG box 1

Related Diseases

Diseases

Alias

Conduct Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14909	TOX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TOX2	VGNC	VGNC:47718
Bos taurus	TOX2	VGNC	VGNC:55084
Felis catus	TOX2	VGNC	VGNC:66459
Rattus norvegicus	TOX2	RGD	RGD:735184
Mus musculus	TOX2	MGD	MGI:3611233
Macaca mulatta	TOX2	VGNC	VGNC:79007

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