2. Gene
  3. PPFIA4 - PTPRF interacting protein alpha 4 Gene

PPFIA4 - PTPRF interacting protein alpha 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 8497 | Gene type: protein coding

About PPFIA4

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:203,026,491-203,078,736 (from NCBI)

This gene has 15 transcripts (splice variants), 210 orthologues and 5 paralogues. Biased expression in brain (RPKM 8.9), heart (RPKM 8.4) and 10 other tissues.

Summary

PPFIA4, or liprin-alpha-4, belongs to the liprin-alpha gene family. See liprin-alpha-1 (LIP1, or PPFIA1; MIM 611054) for background on liprins.[supplied by OMIM, Mar 2008]

PPFIA4 Products(10)

mRNA Protein Name
NM_001304331.2 NP_001291260.1 liprin-alpha-4 isoform 1
NM_001304332.2 NP_001291261.1 liprin-alpha-4 isoform 2
NM_001393950.1 NP_001380879.1 liprin-alpha-4 isoform 3
NM_001393951.1 NP_001380880.1 liprin-alpha-4 isoform 4
NM_001393952.1 NP_001380881.1 liprin-alpha-4 isoform 5
NM_001393953.1 NP_001380882.1 liprin-alpha-4 isoform 6
NM_001393954.1 NP_001380883.1 liprin-alpha-4 isoform 7
NM_001393955.1 NP_001380884.1 liprin-alpha-4 isoform 8
NM_001393956.1 NP_001380885.1 liprin-alpha-4 isoform 9
NM_001393957.1 NP_001380886.1 liprin-alpha-4 isoform 10
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12923177 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPFIA4 Protein Structure

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (828 - 891)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (944 - 1006)

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (1029 - 1098)

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  • 1185 a.a.
Protein Preferred Names Protein Names

liprin-alpha-4

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4

Related Diseases

Diseases Alias
Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi

Cloves Syndrome

Clove Syndrome

Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi, And Skeletal/Spinal Abnormalities

Clove Syndrome, Somatic

Nevus

Congenital Lipomatous Overgrowth - Vascular Malformation - Epidermal Nevi

Congenital Lipomatous Overgrowth-Vascular Malformation-Epidermal Nevi-Skeletal Anomaly Syndrome

Congenital Lipomatous Overgrowth-Vascular Malformation-Epidermal Nevi-Spinal Anomaly Syndrome

CLOVE

Congenital Lipomatous Overgrowth Vascular Malformations Epidermal Nevi And Skeletal/Spinal Abnormalities

Congenital Arteriovenous Malformation

Arteriovenous Hemangioma

Melanocytic Nevus

Benign Melanocytic Nevus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10942 PPFIA4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PPFIA4 VGNC VGNC:33192
Rattus norvegicus PPFIA4 RGD RGD:620055
Canis familiaris PPFIA4 VGNC VGNC:44846
Mus musculus PPFIA4 MGD MGI:1915757
Felis catus PPFIA4 VGNC VGNC:68984
Macaca mulatta PPFIA4 VGNC VGNC:76237