2. Gene
  3. ATG4D - autophagy related 4D cysteine peptidase Gene

ATG4D - autophagy related 4D cysteine peptidase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as APG4D; AUTL4; APG4-D; HsAPG4D

Gene ID: 84971 | Gene type: protein coding

About ATG4D

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,543,904-10,553,418 (from NCBI)

This gene has 12 transcripts (splice variants), 258 orthologues and 3 paralogues. Broad expression in testis (RPKM 21.1), duodenum (RPKM 13.4) and 25 other tissues.

Summary

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of Autophagy have been described in some malignant tumors, and a role for Autophagy in controlling the unregulated cell growth linked to Cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

ATG4D Products(2)

mRNA Protein Name
NM_001281504.2 NP_001268433.1 cysteine protease ATG4D isoform 2
NM_032885.6 NP_116274.3 cysteine protease ATG4D isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables cysteine-type exopeptidase activity IDA
IDA: Inferred from direct assay
21177865 GOA
enables cysteine-type peptidase activity IDA
IDA: Inferred from direct assay
21177865 GOA
Biological Process GO Annotation Evidence Reference Source
involved in autophagosome assembly IDA
IDA: Inferred from direct assay
21177865 GOA
involved in autophagy IDA
IDA: Inferred from direct assay
30661429 GOA
involved in mitophagy IMP
IMP: Inferred from mutant phenotype
33773106 GOA
involved in protein delipidation IDA
IDA: Inferred from direct assay
29458288 GOA
involved in protein localization to phagophore assembly site IMP
IMP: Inferred from mutant phenotype
33773106 GOA
involved in proteolysis IDA
IDA: Inferred from direct assay
21177865 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATG4D Protein Structure

Peptidase_C54

Peptidase_C54: Peptidase family C54 (109 - 412)

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  • 474 a.a.
Protein Preferred Names Protein Names

cysteine protease ATG4D

APG4 autophagy 4 homolog D

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01151 ATG4D Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ATG4D VGNC VGNC:26260
Canis familiaris ATG4D VGNC VGNC:38225
Felis catus ATG4D VGNC VGNC:60005
Macaca mulatta ATG4D VGNC VGNC:108473
Mus musculus ATG4D MGD MGI:2444308
Rattus norvegicus ATG4D RGD RGD:1596392