MMP23B - matrix metallopeptidase 23B Gene

Homo sapiens

Also known as MIFR; MMP22; MIFR-1; MMP23A

Gene ID: 8510 | Gene type: protein coding

About MMP23B

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,632,173-1,634,654 (from NCBI)

This gene has 10 transcripts (splice variants), 186 orthologues, 23 paralogues and is associated with 1 phenotype. Broad expression in placenta (RPKM 4.1), prostate (RPKM 3.5) and 21 other tissues.

Summary

This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the more telomeric copy of the duplicated region. [provided by RefSeq, Jul 2008]

MMP23B Products(1)

mRNA	Protein	Name
NM_006983.2	NP_008914.1	matrix metalloproteinase-23 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	9988691	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MMP23B Protein Structure

Peptidase_M10

ShK

Ig_2

0
100
200
300
390 a.a.

Protein Preferred Names

Protein Names

matrix metalloproteinase-23

MMP-21

Related Diseases

Diseases

Alias

Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome	Deletion 1p36
Monosomy 1p36	Subtelomeric 1p36 Deletion
Monosomy 1p36 Syndrome	Distal Monosomy 1p36
Del(1)(P36)	Deletion 1pter
Monosomy 1pter

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08542	MMP23B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MMP23B	VGNC	VGNC:53594
Felis catus	MMP23B	VGNC	VGNC:82534
Rattus norvegicus	MMP23B	RGD	RGD:620201
Macaca mulatta	MMP23B	VGNC	VGNC:106408
Mus musculus	MMP23B	MGD	MGI:1347361
Canis familiaris	MMP23B	VGNC	VGNC:53425

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