2. Gene
  3. IFITM1 - interferon induced transmembrane protein 1 Gene

IFITM1 - interferon induced transmembrane protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as 9-27; CD225; IFI17; LEU13; DSPA2a

Gene ID: 8519 | Gene type: protein coding

About IFITM1

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:314,040-315,272 (from NCBI)

This gene has 29 transcripts (splice variants), 260 orthologues and 4 paralogues. Ubiquitous expression in spleen (RPKM 191.9), endometrium (RPKM 153.8) and 24 other tissues.

Summary

Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced Antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 that belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]

IFITM1 Products(1)

mRNA Protein Name
NM_003641.5 NP_003632.4 interferon-induced transmembrane protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
2398277 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
20838853 GOA
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
20838853 GOA
involved in negative regulation of viral entry into host cell IDA
IDA: Inferred from direct assay
21253575 GOA
involved in negative regulation of viral genome replication IDA
IDA: Inferred from direct assay
21253575 GOA
involved in negative regulation of viral genome replication IMP
IMP: Inferred from mutant phenotype
21976647 GOA
involved in positive regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
22634173 GOA
involved in response to interferon-alpha IDA
IDA: Inferred from direct assay
22479637 GOA
involved in response to interferon-beta IDA
IDA: Inferred from direct assay
21253575 GOA
involved in response to type II interferon IDA
IDA: Inferred from direct assay
21253575 GOA
involved in response to virus IDA
IDA: Inferred from direct assay
21253575 GOA
Cellular Component GO Annotation Evidence Reference Source
located in lysosomal membrane IDA
IDA: Inferred from direct assay
26354436 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
26354436 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
28246125 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFITM1 Protein Structure

CD225

CD225: Interferon-induced transmembrane protein (21 - 100)

  • 0
  • 100
  • 125 a.a.
Protein Preferred Names Protein Names

interferon-induced transmembrane protein 1

dispanin subfamily A member 2a

IFITM1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83321 IFITM1 Antibody (YA3066) WB, IHC-F, IHC-P, ICC/IF, IP Human

Related Diseases

Diseases Alias
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified
West Nile Virus

West Nile Virus, Susceptibility To

Wnv

Wnv, Susceptibility To

West Nile Viral Infection

Encephalitis, West Nile Fever

West Nile Fever
Dengue Virus

Dengue Virus, Susceptibility To

Dengue Fever, Protection Against

Dengue Fever
Rift Valley Fever

Rfv - [Rift Valley Fever]
Hepatitis C Virus

Hepatitis C Virus, Susceptibility To

Hepatitis C Virus Infection, Response To Therapy Of

Hcv

Hcv, Susceptibility To

Hepatitis C Virus, Resistance To

Hepatitis C Virus, Response To Therapy Of

Resistance To Hepatitis C Virus
Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus
Inflammatory Bowel Disease 27

IBD27
Cervical Cancer

Cervical Cancer, Somatic

Neoplasm Of Uterine Cervix

Cervix Cancer

Uterine Cervical Neoplasm

Cervical Neoplasm

Cervix Uteri Cancer

Tumor Of The Cervix Uteri

CERCA

Uterine Cervical Cancer

Neoplasms Cervical

Uterine Cervical Neoplasms

Cervical Cancers

Cancer, Cervical, Somatic

Malignant Tumor Of Cervix

Cervix Carcinoma
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06565 IFITM1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus IFITM1 MGD MGI:1915963
Rattus norvegicus IFITM1 RGD RGD:1307601